• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Maximum margin classifier working in a set of strings.在一组字符串中工作的最大间隔分类器。
Proc Math Phys Eng Sci. 2016 Mar;472(2187):20150551. doi: 10.1098/rspa.2015.0551.
2
Fast exact algorithms for the closest string and substring problems with application to the planted (L, d)-motif model.快速精确算法求解最接近字符串和子字符串问题及其在 (L, d)-基序模型中的应用。
IEEE/ACM Trans Comput Biol Bioinform. 2011 Sep-Oct;8(5):1400-10. doi: 10.1109/TCBB.2011.21.
3
Fast motif recognition via application of statistical thresholds.通过应用统计阈值进行快速基序识别。
BMC Bioinformatics. 2010 Jan 18;11 Suppl 1(Suppl 1):S11. doi: 10.1186/1471-2105-11-S1-S11.
4
Implementation of a Hamming distance-like genomic quantum classifier using inner products on ibmqx2 and ibmq_16_melbourne.在ibmqx2和ibmq_16_melbourne上使用内积实现类似汉明距离的基因组量子分类器。
Quantum Mach Intell. 2020;2(1):1-26. doi: 10.1007/s42484-020-00017-7. Epub 2020 Jul 17.
5
Closest string with outliers.带有异常值的最近字符串。
BMC Bioinformatics. 2011 Feb 15;12 Suppl 1(Suppl 1):S55. doi: 10.1186/1471-2105-12-S1-S55.
6
On Supervised Classification of Feature Vectors with Independent and Non-Identically Distributed Elements.关于具有独立且非均匀分布元素的特征向量的监督分类
Entropy (Basel). 2021 Aug 13;23(8):1045. doi: 10.3390/e23081045.
7
Performance of a Machine Learning Classifier of Knee MRI Reports in Two Large Academic Radiology Practices: A Tool to Estimate Diagnostic Yield.在两家大型学术放射科实践中膝关节MRI报告的机器学习分类器性能:一种估计诊断率的工具
AJR Am J Roentgenol. 2017 Apr;208(4):750-753. doi: 10.2214/AJR.16.16128. Epub 2017 Jan 31.
8
Experimental and Computer Simulation Studies on Badminton Racquet Strings.羽毛球拍弦的实验和计算机模拟研究。
Sensors (Basel). 2023 Jun 27;23(13):5957. doi: 10.3390/s23135957.
9
A memory-efficient data structure representing exact-match overlap graphs with application for next-generation DNA assembly.一种内存效率高的数据结构,用于表示精确匹配的重叠图,适用于下一代 DNA 组装。
Bioinformatics. 2011 Jul 15;27(14):1901-7. doi: 10.1093/bioinformatics/btr321. Epub 2011 Jun 2.
10
Prototype classification: insights from machine learning.原型分类:机器学习的见解
Neural Comput. 2009 Jan;21(1):272-300. doi: 10.1162/neco.2008.01-07-443.

本文引用的文献

1
Rfam 12.0: updates to the RNA families database.Rfam 12.0:RNA家族数据库的更新
Nucleic Acids Res. 2015 Jan;43(Database issue):D130-7. doi: 10.1093/nar/gku1063. Epub 2014 Nov 11.
2
Biological sequence classification with multivariate string kernels.
IEEE/ACM Trans Comput Biol Bioinform. 2013 Sep-Oct;10(5):1201-10. doi: 10.1109/TCBB.2013.15.
3
3did: a catalog of domain-based interactions of known three-dimensional structure.3did:已知三维结构的基于域的相互作用目录。
Nucleic Acids Res. 2014 Jan;42(Database issue):D374-9. doi: 10.1093/nar/gkt887. Epub 2013 Sep 29.
4
The RCSB Protein Data Bank: redesigned web site and web services.RCSB蛋白质数据库:重新设计的网站和网络服务。
Nucleic Acids Res. 2011 Jan;39(Database issue):D392-401. doi: 10.1093/nar/gkq1021. Epub 2010 Oct 29.
5
Exploiting physico-chemical properties in string kernels.利用字符串核中的物理化学性质。
BMC Bioinformatics. 2010 Oct 26;11 Suppl 8(Suppl 8):S7. doi: 10.1186/1471-2105-11-S8-S7.
6
Quantifying biodiversity and asymptotics for a sequence of random strings.量化随机字符串序列的生物多样性和渐近性质。
Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Jun;81(6 Pt 1):061912. doi: 10.1103/PhysRevE.81.061912. Epub 2010 Jun 7.
7
Physicochemical property distributions for accurate and rapid pairwise protein homology detection.用于准确快速进行蛋白质两两同源性检测的理化性质分布。
BMC Bioinformatics. 2010 Mar 19;11:145. doi: 10.1186/1471-2105-11-145.
8
TargetMiner: microRNA target prediction with systematic identification of tissue-specific negative examples.TargetMiner:通过系统识别组织特异性负例进行 microRNA 靶标预测。
Bioinformatics. 2009 Oct 15;25(20):2625-31. doi: 10.1093/bioinformatics/btp503. Epub 2009 Aug 19.
9
Efficient use of unlabeled data for protein sequence classification: a comparative study.蛋白质序列分类中未标记数据的高效利用:一项比较研究。
BMC Bioinformatics. 2009 Apr 29;10 Suppl 4(Suppl 4):S2. doi: 10.1186/1471-2105-10-S4-S2.
10
Remote protein homology detection using recurrence quantification analysis and amino acid physicochemical properties.利用递归定量分析和氨基酸理化性质进行远程蛋白质同源性检测。
J Theor Biol. 2008 May 7;252(1):145-54. doi: 10.1016/j.jtbi.2008.01.028. Epub 2008 Feb 7.

在一组字符串中工作的最大间隔分类器。

Maximum margin classifier working in a set of strings.

作者信息

Koyano Hitoshi, Hayashida Morihiro, Akutsu Tatsuya

机构信息

Laboratory of Biostatistics and Bioinformatics , Graduate School of Medicine, Kyoto University , 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

Laboratory of Mathematical Bioinformatics , Institute for Chemical Research, Kyoto University , Gokasho, Uji, Kyoto 611-0011, Japan.

出版信息

Proc Math Phys Eng Sci. 2016 Mar;472(2187):20150551. doi: 10.1098/rspa.2015.0551.

DOI:10.1098/rspa.2015.0551
PMID:27118908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4841474/
Abstract

Numbers and numerical vectors account for a large portion of data. However, recently, the amount of string data generated has increased dramatically. Consequently, classifying string data is a common problem in many fields. The most widely used approach to this problem is to convert strings into numerical vectors using string kernels and subsequently apply a support vector machine that works in a numerical vector space. However, this non-one-to-one conversion involves a loss of information and makes it impossible to evaluate, using probability theory, the generalization error of a learning machine, considering that the given data to train and test the machine are strings generated according to probability laws. In this study, we approach this classification problem by constructing a classifier that works in a set of strings. To evaluate the generalization error of such a classifier theoretically, probability theory for strings is required. Therefore, we first extend a limit theorem for a consensus sequence of strings demonstrated by one of the authors and co-workers in a previous study. Using the obtained result, we then demonstrate that our learning machine classifies strings in an asymptotically optimal manner. Furthermore, we demonstrate the usefulness of our machine in practical data analysis by applying it to predicting protein-protein interactions using amino acid sequences and classifying RNAs by the secondary structure using nucleotide sequences.

摘要

数字和数值向量占据了数据的很大一部分。然而,近年来,生成的字符串数据量急剧增加。因此,对字符串数据进行分类是许多领域中常见的问题。解决这个问题最广泛使用的方法是使用字符串核将字符串转换为数值向量,随后应用在数值向量空间中工作的支持向量机。然而,这种非一对一的转换会导致信息丢失,并且由于用于训练和测试机器的给定数据是根据概率定律生成的字符串,因此无法使用概率论来评估学习机器的泛化误差。在本研究中,我们通过构建在一组字符串中工作的分类器来解决这个分类问题。为了从理论上评估这种分类器的泛化误差,需要字符串的概率论。因此,我们首先扩展了一位作者及其同事在先前研究中证明的字符串一致序列的极限定理。利用得到的结果,我们证明了我们的学习机器以渐近最优的方式对字符串进行分类。此外,我们通过将其应用于使用氨基酸序列预测蛋白质 - 蛋白质相互作用以及使用核苷酸序列按二级结构对RNA进行分类,证明了我们的机器在实际数据分析中的有用性。