Huang Jianpan, Zhang Miao, Lu Jianhua, Cai Congbo, Chen Lin, Cai Shuhui
Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China.
Meizhouwan Vocational Technology College, Putian, China.
Magn Reson Med. 2017 May;77(5):1786-1796. doi: 10.1002/mrm.26258. Epub 2016 Apr 27.
To design a new approach that can not only keep the spatial and temporal resolution but also have better built-in immunity to magnetic field inhomogeneity and chemical shift effects than the single-shot echo planar imaging (EPI) for chemical exchange saturation transfer (CEST) MRI.
The single-shot spatiotemporally encoded (SPEN) MRI sequence was combined with a continuous wave saturation pulse for fast CEST MRI (CEST-SPEN MRI). The resulting images were super-resolved reconstructed by a hybrid method that solves the l norm minimization together with total variation (TV) regularization. Partial Lorentzian fitting was used to analyze the subsequent Z-spectra.
Experimental results of a creatine phantom and in vivo tumor rat brains show that CEST-SPEN MRI has good capability in providing CEST-based and NOE-based contrast images.
Compared with CEST-EPI, CEST-SPEN MRI has better immunity to magnetic field inhomogeneity and provides better contrast images within identical acquisition time, especially under an identical inhomogeneous field. Magn Reson Med 77:1786-1796, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
设计一种新方法，该方法不仅能保持空间和时间分辨率，而且与用于化学交换饱和转移（CEST）磁共振成像（MRI）的单次激发回波平面成像（EPI）相比，对磁场不均匀性和化学位移效应具有更好的内在免疫能力。
将单次激发时空编码（SPEN）MRI序列与连续波饱和脉冲相结合用于快速CEST MRI（CEST-SPEN MRI）。通过一种结合l范数最小化和总变分（TV）正则化的混合方法对所得图像进行超分辨率重建。使用部分洛伦兹拟合来分析后续的Z谱。
肌酸模型和体内肿瘤大鼠脑的实验结果表明，CEST-SPEN MRI在提供基于CEST和基于核Overhauser效应（NOE）的对比图像方面具有良好能力。
与CEST-EPI相比，CEST-SPEN MRI对磁场不均匀性具有更好的免疫能力，并且在相同采集时间内，尤其是在相同的不均匀场下，能提供更好的对比图像。《磁共振医学》77:1786 - 1796, 2017。© 2016国际磁共振医学学会。
