Saiyisan Ahelijiang, Zeng Shihao, Zhang Huabin, Wang Ziyan, Wang Jiawen, Cai Pei, Huang Jianpan
Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, Anhui Province, China.
Neural Regen Res. 2026 Feb 1;21(2):553-568. doi: 10.4103/NRR.NRR-D-24-01246. Epub 2025 Jan 29.
Chemical exchange saturation transfer magnetic resonance imaging is an advanced imaging technique that enables the detection of compounds at low concentrations with high sensitivity and spatial resolution and has been extensively studied for diagnosing malignancy and stroke. In recent years, the emerging exploration of chemical exchange saturation transfer magnetic resonance imaging for detecting pathological changes in neurodegenerative diseases has opened up new possibilities for early detection and repetitive scans without ionizing radiation. This review serves as an overview of chemical exchange saturation transfer magnetic resonance imaging with detailed information on contrast mechanisms and processing methods and summarizes recent developments in both clinical and preclinical studies of chemical exchange saturation transfer magnetic resonance imaging for Alzheimer's disease, Parkinson's disease, multiple sclerosis, and Huntington's disease. A comprehensive literature search was conducted using databases such as PubMed and Google Scholar, focusing on peer-reviewed articles from the past 15 years relevant to clinical and preclinical applications. The findings suggest that chemical exchange saturation transfer magnetic resonance imaging has the potential to detect molecular changes and altered metabolism, which may aid in early diagnosis and assessment of the severity of neurodegenerative diseases. Although promising results have been observed in selected clinical and preclinical trials, further validations are needed to evaluate their clinical value. When combined with other imaging modalities and advanced analytical methods, chemical exchange saturation transfer magnetic resonance imaging shows potential as an in vivo biomarker, enhancing the understanding of neuropathological mechanisms in neurodegenerative diseases.
化学交换饱和转移磁共振成像（Chemical exchange saturation transfer magnetic resonance imaging，CEST-MRI）是一种先进的成像技术，能够高灵敏度、高空间分辨率地检测低浓度化合物，并且已被广泛研究用于诊断恶性肿瘤和中风。近年来，CEST-MRI在检测神经退行性疾病病理变化方面的新探索，为早期检测和无电离辐射的重复扫描开辟了新的可能性。本综述概述了CEST-MRI，详细介绍了其对比机制和处理方法，并总结了CEST-MRI在阿尔茨海默病、帕金森病、多发性硬化症和亨廷顿病临床及临床前研究中的最新进展。使用PubMed和谷歌学术等数据库进行了全面的文献检索，重点关注过去15年中与临床和临床前应用相关的同行评审文章。研究结果表明，CEST-MRI有潜力检测分子变化和代谢改变，这可能有助于神经退行性疾病的早期诊断和严重程度评估。尽管在部分临床和临床前试验中已观察到有前景的结果，但仍需要进一步验证以评估其临床价值。当与其他成像模式和先进分析方法结合时，CEST-MRI显示出作为体内生物标志物的潜力，有助于加深对神经退行性疾病神经病理机制的理解。
