Hirakawa T, Tsuneyoshi M, Enjoji M
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Am J Surg Pathol. 1989 May;13(5):397-405. doi: 10.1097/00000478-198905000-00007.
Clinical and pathologic features of 28 patients with squamous cell carcinoma (SCC) arising in mature cystic teratoma (MCT) of the ovary were analyzed. The overall 5-year survival rate of these patients was 52%. Clinical staging (Stage I versus Stages II or more), histologic differentiation (well versus moderately or poorly differentiated SCC), and the presence of vascular invasion were factors affecting the prognosis of these patients. In 11 tumors, including 2 of the 4 examined in stepwise serial sections, the SCC was considered to have originated from a columnar epithelium (ciliated or nonciliated) or from a metaplastic squamous epithelium. On the other hand, no SCC was a direct transition from the ordinary epidermis of the teratomatous skin tissue. These results strongly support the proposal that SCC arising in MCT derives from the columnar epithelium.
分析了28例卵巢成熟性囊性畸胎瘤（MCT）中发生的鳞状细胞癌（SCC）患者的临床和病理特征。这些患者的总体5年生存率为52%。临床分期（I期与II期或更晚期）、组织学分化（高分化与中分化或低分化SCC）以及血管侵犯的存在是影响这些患者预后的因素。在11个肿瘤中，包括连续切片检查的4个中的2个，SCC被认为起源于柱状上皮（纤毛或非纤毛）或化生的鳞状上皮。另一方面，没有SCC是畸胎瘤皮肤组织普通表皮的直接转变。这些结果有力地支持了MCT中发生的SCC起源于柱状上皮的观点。
