Inoue H, Ichinose M, Miura M, Katsumata U, Takishima T
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Am Rev Respir Dis. 1989 May;139(5):1175-8. doi: 10.1164/ajrccm/139.5.1175.
The sensory receptors and reflex pathways of the nonadrenergic inhibitory nervous system (NAINS) were examined, using separately ventilated left and right lungs in cats. During bronchoconstriction induced by 5-hydroxytryptamine (5-HT) (50 to 250 micrograms/kg/min, i.v.) infusion after atropine (3 mg/kg, i.v.) and propranolol (2 mg/kg, i.v.), one lung was challenged with (1) citric acid aerosol or (2) capsaicin aerosol or (3) lung volume change (lung inflation). Citric acid or capsaicin inhalation to one lung produced significant bronchodilatation in not only the stimulated lung (SL) but also in the opposite lung (OL). The 5-HT-induced change in pulmonary resistance (RL) was reduced 66.5 +/- 3.3% (mean +/- 1 SE) (SL) and 53.0 +/- 8.1% (OL) by citric acid (20%) and 40.5 +/- 8.9% (SL) and 44.0 +/- 9.9% (OL) by capsaicin (0.1%) inhalation, respectively. These bronchodilatations were abolished by bilateral vagotomy. Inflation of one side of the lung did not reduce the 5-HT-induced change in RL in the OL. These findings indicate that (1) C-fiber and irritant receptors are the possible sensory receptors of the NAINS reflex pathway, and (2) afferent nerve stimulation of NAINS in one lung can produce reflex bronchodilatation in both lungs.
利用猫的左、右肺分别通气，对非肾上腺素能抑制神经系统（NAINS）的感觉受体和反射通路进行了研究。在静脉注射阿托品（3mg/kg）和普萘洛尔（2mg/kg）后，通过静脉输注5-羟色胺（5-HT）（50至250微克/千克/分钟）诱导支气管收缩，然后对一侧肺进行以下刺激：（1）柠檬酸气雾剂；（2）辣椒素气雾剂；（3）肺容量变化（肺膨胀）。向一侧肺吸入柠檬酸或辣椒素不仅能使受刺激的肺（SL），还能使对侧肺（OL）产生显著的支气管扩张。吸入20%柠檬酸可使5-HT引起的肺阻力（RL）变化在SL中降低66.5±3.3%（平均值±1标准误），在OL中降低53.0±8.1%；吸入0.1%辣椒素可使SL中降低40.5±8.9%，OL中降低44.0±9.9%。这些支气管扩张作用在双侧迷走神经切断后消失。一侧肺膨胀并不能降低OL中5-HT引起的RL变化。这些发现表明：（1）C纤维和刺激感受器可能是NAINS反射通路的感觉受体；（2）一侧肺中NAINS的传入神经刺激可使双侧肺产生反射性支气管扩张。
