脂肪酸氧化的遗传变异与肥胖：文献综述
Genetic Variation of Fatty Acid Oxidation and Obesity, A Literature Review.
作者信息
Freitag Luglio Harry
机构信息
Department of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Indonesia.
出版信息
Int J Biomed Sci. 2016 Mar;12(1):1-8.
Abstract
Modulation of fat metabolism is an important component of the etiology of obesity as well as individual response to weight loss program. The influence of lipolysis process had receives many attentions in recent decades. Compared to that, fatty acid oxidation which occurred after lipolysis seems to be less exposed. There are limited publications on how fatty acid oxidation influences predisposition to obesity, especially the importance of genetic variations of fatty acid oxidation proteins on development of obesity. The aim of this review is to provide recent knowledge on how polymorphism of genes related fatty acid oxidation is obtained. Studies in human as well as animal model showed that disturbance of genes related fatty acid oxidation process gave impact on body weight and risks to obesity. Several polymorphisms on CD36, CPT, ACS and FABP had been shown to be related to obesity either by regulating enzymatic activity or directly influence fatty acid oxidation process.
摘要
脂肪代谢的调节是肥胖病因以及个体对减肥计划反应的重要组成部分。近几十年来，脂解过程的影响受到了许多关注。相比之下，脂解后发生的脂肪酸氧化似乎较少受到关注。关于脂肪酸氧化如何影响肥胖易感性的出版物有限，尤其是脂肪酸氧化蛋白的基因变异对肥胖发展的重要性。本综述的目的是提供有关如何获得与脂肪酸氧化相关基因多态性的最新知识。对人类以及动物模型的研究表明，与脂肪酸氧化过程相关的基因紊乱会影响体重和肥胖风险。已表明CD36、CPT、ACS和FABP上的几种多态性通过调节酶活性或直接影响脂肪酸氧化过程与肥胖有关。
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