患有呼吸道过敏的儿童中针对空气传播真菌的IgE血清浓度。
IgE serum concentration against airborne fungi in children with respiratory allergies.
作者信息
de Barros Bezerra Geusa Felipa, Haidar Denise Maria Costa, da Silva Marcos Antonio Custódio Neto, Filho Walbert Edson Muniz, Dos Santos Ramon Moura, Rosa Ivone Garros, de Castro Viana Graça Maria, Zaror Luís, Soares Brandão Nascimento Maria do Desterro
机构信息
Postgraduate building of the Center for Life Sciences and Health, Federal University of Maranhão, Portuguese Avenue, 1966, Bacanga, São Luís, MA CEP 65080-805 Brazil.
Maternal and Child University Hospital, Street Barão of Itapary, 227, Center, São Luís, MA Brazil.
出版信息
Allergy Asthma Clin Immunol. 2016 Apr 27;12:18. doi: 10.1186/s13223-016-0128-y. eCollection 2016.
BACKGROUND
To evaluate total and specific E immunoglobulin (IgE) antibody concentrations in underage subjects with respiratory allergic diseases.
METHODS
This study was a transversal-type study in 100 underage subjects between 4 and 14 years old, with asthma and/or allergic rhinitis. Total and specific IgE were quantified for airborne fungi in the city of São Luís, Maranhão, Brazil. Five distinct regions-North, South, Center, East and West-were selected so fungi could be collected monthly for 1 year. Twenty genera were identified. Aspergillus, Penicillium, Fusarium and Neurospora were selected for the preparation of sensitizing antigens from ELISA dishes. IgE total concentrations were estimated using the same method.
RESULTS
IgE total serum concentration was increased in 97 % of the atopic subjects: 75 % of the subjects presented increased IgE anti-Aspergillus concentrations, 87 % presented IgE anti-Penicillium, 45 % presented IgE anti-Fusarium, and 46 % presented IgE anti-Neurospora.
CONCLUSIONS
Atopic subjects presented simultaneous IgE total and specific elevations for the tested fungi, possibly due to polysensitization caused by the presence of fungi in all of the areas all year. However, determining the clinical significance of the results was not yet possible because most of the data were isolated variables.
背景
评估患有呼吸道过敏性疾病的未成年受试者中E免疫球蛋白（IgE）抗体的总浓度和特异性浓度。
方法
本研究是一项横断面研究，对100名4至14岁患有哮喘和/或过敏性鼻炎的未成年受试者进行。对巴西马拉尼昂州圣路易斯市空气中的真菌进行了总IgE和特异性IgE的定量分析。选择了五个不同的区域——北部、南部、中部、东部和西部——以便在1年的时间里每月收集真菌。鉴定出了20个属。选择曲霉菌属、青霉菌属、镰刀菌属和脉孢菌属，从酶联免疫吸附测定板中制备致敏抗原。总IgE浓度采用相同方法进行估算。
结果
97%的特应性受试者血清总IgE浓度升高：75%的受试者抗曲霉菌IgE浓度升高，87%的受试者抗青霉菌IgE升高，45%的受试者抗镰刀菌IgE升高，46%的受试者抗脉孢菌IgE升高。
结论
特应性受试者针对所检测真菌的总IgE和特异性IgE同时升高可能是由于全年所有区域均存在真菌导致的多致敏现象。然而，由于大多数数据都是孤立变量，目前尚无法确定这些结果的临床意义。
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