Maioli M, Pettinato S, Cherchi G M, Giraudi D, Pacifico A, Pupita G, Tidore M G
Cattedra di Diabetologia, Facoltà di Medicina, Università di Sassari, Italy.
Atherosclerosis. 1989 Feb;75(2-3):245-8. doi: 10.1016/0021-9150(89)90182-2.
Because total cholesterol levels have been found to be lower in patients affected by thalassemia major and intermedia, we examined the plasma lipid pattern of 628 beta-thalassemia trait carriers and 4552 controls in order to evaluate whether the plasma lipid impairment is also present in the heterozygous state. Total cholesterol and low density lipoprotein (LDL)-cholesterol levels were significantly lower in beta-thalassemia trait carriers when compared to controls, whereas plasma triglycerides and high density lipoprotein (HDL)-cholesterol levels did not differ between the two groups. We suggest that accelerated erythropoiesis and increased uptake of LDL by macrophages and histiocytes of the reticuloendothelial system are the main determinants of low plasma cholesterol levels in heterozygous thalassemia.
由于已发现重型和中间型地中海贫血患者的总胆固醇水平较低，我们检测了628例β地中海贫血特征携带者和4552例对照者的血浆脂质模式，以评估杂合状态下是否也存在血浆脂质损害。与对照组相比，β地中海贫血特征携带者的总胆固醇和低密度脂蛋白（LDL）胆固醇水平显著降低，而两组之间的血浆甘油三酯和高密度脂蛋白（HDL）胆固醇水平没有差异。我们认为，红细胞生成加速以及网状内皮系统的巨噬细胞和组织细胞对LDL摄取增加是杂合型地中海贫血患者血浆胆固醇水平降低的主要决定因素。
