淀粉样蛋白成像、脑脊液生物标志物可预测认知正常个体的驾驶能力
Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals.
作者信息
Roe Catherine M, Barco Peggy P, Head Denise M, Ghoshal Nupur, Selsor Natalie, Babulal Ganesh M, Fierberg Rebecca, Vernon Elizabeth K, Shulman Neal, Johnson Ann, Fague Scot, Xiong Chengjie, Grant Elizabeth A, Campbell Angela, Ott Brian R, Holtzman David M, Benzinger Tammie L S, Fagan Anne M, Carr David B, Morris John C
机构信息
*Charles F. and Joanne Knight Alzheimer's Disease Research Center Departments of †Neurology ‡Occupational Therapy ∥Psychology ¶¶Pathology and Immunology ##Physical Therapy **Radiology §§Neurosurgery ∥∥Medicine ¶Center for Clinical Studies #Division of Biostatistics, Washington University School of Medicine, St. Louis, MO §The Rehabilitation Institute of St. Louis ††The Alzheimer's Disease & Memory Disorders Center, Alpert Medical School of Brown University ‡‡Rhode Island Hospital, Providence, Rhode Island.
出版信息
Alzheimer Dis Assoc Disord. 2017 Jan-Mar;31(1):69-72. doi: 10.1097/WAD.0000000000000154.
Postmortem brain studies of older drivers killed in car accidents indicate that many had Alzheimer disease (AD) neuropathologic changes. We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and driving at least once per week, were recruited. Participants (N=129) took part in clinical assessments, a driving test, and positron emission tomography imaging with Pittsburgh compound B (PIB) and/or cerebrospinal fluid (CSF) collection. General linear models tested whether the number of driving errors differed as a function of each of the biomarker variables (mean cortical binding potential for PIB, and CSF Aβ42, tau, ptau181, tau/Aβ42, ptau181/Aβ42). Higher ratios of CSF tau/Aβ42, ptau181/Aβ42, and PIB mean cortical binding potential, were associated with more driving errors (P<0.05). Preclinical AD may have subtle cognitive and functional effects, which alone may go unnoticed. However, when combined, these changes may impact complex behaviors such as driving.
对在车祸中丧生的老年驾驶员进行的尸检脑部研究表明，许多人存在阿尔茨海默病（AD）神经病理学变化。我们研究了AD生物标志物是否与认知正常的老年人的驾驶性能相关。招募了年龄在65岁及以上、认知正常且每周至少驾驶一次的个体。参与者（N = 129）接受了临床评估、驾驶测试以及使用匹兹堡化合物B（PIB）的正电子发射断层扫描成像和/或脑脊液（CSF）采集。通用线性模型测试了驾驶错误数量是否因每个生物标志物变量（PIB的平均皮质结合潜力以及CSF Aβ42、tau、ptau181、tau/Aβ42、ptau181/Aβ42）而有所不同。CSF tau/Aβ42、ptau181/Aβ42的比率较高以及PIB平均皮质结合潜力较高，与更多的驾驶错误相关（P<0.05）。临床前AD可能具有细微的认知和功能影响，这些影响单独可能未被注意到。然而，当这些变化综合起来时，可能会影响诸如驾驶等复杂行为。
Zotero 插件