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Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report.神经精神症状与阿尔茨海默病生物标志物可预测驾驶能力下降：简要报告
J Alzheimers Dis. 2017;58(3):675-680. doi: 10.3233/JAD-170067.
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Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.抑郁和阿尔茨海默病生物标志物可预测驾驶能力下降。
J Alzheimers Dis. 2018;66(3):1213-1221. doi: 10.3233/JAD-180564.
3
Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults.阿尔茨海默病生物标志物与认知正常老年人群的未来衰退。
J Alzheimers Dis. 2017;60(4):1451-1459. doi: 10.3233/JAD-170511.
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Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels.认知正常的老年人的情绪变化与阿尔茨海默病生物标志物水平有关。
Am J Geriatr Psychiatry. 2016 Nov;24(11):1095-1104. doi: 10.1016/j.jagp.2016.04.004. Epub 2016 Apr 19.
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Identifying Preclinical Alzheimer's Disease Using Everyday Driving Behavior: Proof of Concept.利用日常驾驶行为识别临床前阿尔茨海默病：概念验证。
J Alzheimers Dis. 2021;79(3):1009-1014. doi: 10.3233/JAD-201294.
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Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid.磷酸化tau蛋白与Aβ42的比值作为一种连续性状，用于在脑脊液多重免疫分析检测板中发现早期阿尔茨海默病的生物标志物。
Biol Psychiatry. 2014 May 1;75(9):723-31. doi: 10.1016/j.biopsych.2013.11.032. Epub 2014 Jan 19.
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Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples.主观认知衰退患者中异常阿尔茨海默病生物标志物的流行率：三个欧洲记忆诊所样本的横断面比较。
Alzheimers Res Ther. 2019 Jan 17;11(1):8. doi: 10.1186/s13195-018-0463-y.
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CSF biomarkers of Alzheimer disease: "noncognitive" outcomes.阿尔茨海默病的脑脊液生物标志物：“非认知”结局。
Neurology. 2013 Dec 3;81(23):2028-31. doi: 10.1212/01.wnl.0000436940.78152.05. Epub 2013 Nov 8.
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Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study.轻度认知障碍患者脑脊液生物标志物与早期阿尔茨海默病的关联：一项随访研究。
Lancet Neurol. 2006 Mar;5(3):228-34. doi: 10.1016/S1474-4422(06)70355-6.
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Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study.阿尔茨海默病脑脊液标志物的记忆相关性：一项纵向队列研究。
J Alzheimers Dis. 2017;60(3):1119-1128. doi: 10.3233/JAD-160766.
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Updates and future perspectives on neuropsychiatric symptoms in Alzheimer's disease.阿尔茨海默病神经精神症状的最新进展与未来展望
Alzheimers Dement. 2025 Mar;21(3):e70079. doi: 10.1002/alz.70079.
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Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults.认知正常的老年人抑郁症状的变化与纵向区域性淀粉样蛋白积累。
JAMA Netw Open. 2024 Aug 1;7(8):e2427248. doi: 10.1001/jamanetworkopen.2024.27248.
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Plasma neurofilament light, glial fibrillary acid protein, and phosphorylated tau 181 as biomarkers for neuropsychiatric symptoms and related clinical disease progression.血浆神经丝轻链、胶质纤维酸性蛋白和磷酸化 tau181 作为神经精神症状和相关临床疾病进展的生物标志物。
Alzheimers Res Ther. 2024 Jul 25;16(1):165. doi: 10.1186/s13195-024-01526-4.
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Plasma neurofilament light, glial fibrillary acid protein, and phosphorylated tau 181 as biomarkers for neuropsychiatric symptoms and related clinical disease progression.血浆神经丝轻链、胶质纤维酸性蛋白和磷酸化tau 181作为神经精神症状及相关临床疾病进展的生物标志物。
Res Sq. 2024 Mar 22:rs.3.rs-4116836. doi: 10.21203/rs.3.rs-4116836/v1.
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Driving and Alzheimer's dementia or mild cognitive impairment: a systematic review of the existing guidelines emphasizing on the neurologist's role.驾驶与阿尔茨海默病或轻度认知障碍：现有指南的系统综述，重点强调神经科医生的作用。
Neurol Sci. 2021 Dec;42(12):4953-4963. doi: 10.1007/s10072-021-05610-7. Epub 2021 Sep 28.
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GPS driving: a digital biomarker for preclinical Alzheimer disease.GPS 驾驶：临床前阿尔茨海默病的数字生物标志物。
Alzheimers Res Ther. 2021 Jun 14;13(1):115. doi: 10.1186/s13195-021-00852-1.
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Using Naturalistic Driving Data to Predict Mild Cognitive Impairment and Dementia: Preliminary Findings from the Longitudinal Research on Aging Drivers (LongROAD) Study.利用自然驾驶数据预测轻度认知障碍和痴呆症：老年驾驶员纵向研究（LongROAD）的初步结果
Geriatrics (Basel). 2021 Apr 23;6(2):45. doi: 10.3390/geriatrics6020045.
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The Effect of Type 2 Diabetes Mellitus on Neuropsychological Symptoms in Chinese Early Alzheimer's Disease Population.2型糖尿病对中国早期阿尔茨海默病患者神经心理症状的影响。
Neuropsychiatr Dis Treat. 2020 Mar 26;16:829-836. doi: 10.2147/NDT.S240529. eCollection 2020.
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Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals.轻度行为障碍与β-淀粉样蛋白有关，但与认知正常的老年人的tau 蛋白或神经退行性变无关。
Alzheimers Dement. 2020 Jan;16(1):192-199. doi: 10.1002/alz.12007.
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Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.抑郁和阿尔茨海默病生物标志物可预测驾驶能力下降。
J Alzheimers Dis. 2018;66(3):1213-1221. doi: 10.3233/JAD-180564.
本文引用的文献
1
Preclinical Alzheimer's disease and longitudinal driving decline.临床前阿尔茨海默病与纵向驾驶能力下降
Alzheimers Dement (N Y). 2017 Jan;3(1):74-82. doi: 10.1016/j.trci.2016.11.006.
2
Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels.认知正常的老年人的情绪变化与阿尔茨海默病生物标志物水平有关。
Am J Geriatr Psychiatry. 2016 Nov;24(11):1095-1104. doi: 10.1016/j.jagp.2016.04.004. Epub 2016 Apr 19.
3
Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals.淀粉样蛋白成像、脑脊液生物标志物可预测认知正常个体的驾驶能力
Alzheimer Dis Assoc Disord. 2017 Jan-Mar;31(1):69-72. doi: 10.1097/WAD.0000000000000154.
4
Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment.神经精神症状作为急性痴呆的早期表现：轻度行为损害的临时诊断标准。
Alzheimers Dement. 2016 Feb;12(2):195-202. doi: 10.1016/j.jalz.2015.05.017. Epub 2015 Jun 18.
5
"Noncognitive" symptoms of early Alzheimer disease: a longitudinal analysis.早期阿尔茨海默病的“非认知”症状：一项纵向分析
Neurology. 2015 Feb 10;84(6):617-22. doi: 10.1212/WNL.0000000000001238.
6
Preclinical Alzheimer disease-the challenges ahead.临床前期阿尔茨海默病——未来的挑战。
Nat Rev Neurol. 2013 Jan;9(1):54-8. doi: 10.1038/nrneurol.2012.241. Epub 2012 Nov 27.
7
Predicting road test performance in drivers with dementia.预测痴呆症患者的路考表现。
J Am Geriatr Soc. 2011 Nov;59(11):2112-7. doi: 10.1111/j.1532-5415.2011.03657.x. Epub 2011 Oct 12.
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Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.为了定义阿尔茨海默病的临床前阶段：来自美国国家老龄化研究所-阿尔茨海默病协会工作组关于阿尔茨海默病诊断指南的建议。
Alzheimers Dement. 2011 May;7(3):280-92. doi: 10.1016/j.jalz.2011.03.003. Epub 2011 Apr 21.
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Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults.脑脊液tau蛋白与β-淀粉样蛋白（42）的比值作为非痴呆老年人认知衰退的预测指标
Arch Neurol. 2007 Mar;64(3):343-9. doi: 10.1001/archneur.64.3.noc60123. Epub 2007 Jan 8.
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Longitudinal driving performance in early-stage dementia of the Alzheimer type.阿尔茨海默病型早期痴呆患者的纵向驾驶表现
J Am Geriatr Soc. 2003 Oct;51(10):1342-7. doi: 10.1046/j.1532-5415.2003.51481.x.
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