Olson D M, Shewmon D A
Department of Neurology, University of California, Los Angeles Medical Center 90024.
Pediatr Neurol. 1989 Mar-Apr;5(2):93-8. doi: 10.1016/0887-8994(89)90033-7.
Electroencephalography (EEG) was performed on 16 neonates between 38-45 weeks conceptional age with hypoplastic left heart syndrome (HLHS). The findings were compared blindly with EEGs recorded from 16 infants with other congenital heart defects and 15 infants referred for EEGs with noncardiac diagnoses or problems. EEGs from HLHS infants demonstrated significantly decreased quiet sleep and increased indeterminate sleep, an abnormally discontinuous tracing in active and indeterminate sleep, and lack of response to stimulation. No significant differences were present in the amount of active sleep, sharp waves, focal slowing, or rhythmic theta activity. The distinctive abnormalities were unrelated to arterial blood gases or treatment with prostaglandin E at recording. Four HLHS infants had repeat recordings performed; there were serial increases in quiet sleep, decreases in indeterminate sleep, and improved continuity in all patients. Certain EEG abnormalities occur more frequently in infants with HLHS than in patients with other cardiac defects or noncardiac problems. These findings may result from the early onset of heart failure and abnormal cerebral perfusion due to hypoplasia of the ascending aorta and great arteries, conditions commonly associated with HLHS.
对16名孕龄在38至45周之间的左心发育不全综合征（HLHS）新生儿进行了脑电图（EEG）检查。研究结果与16名患有其他先天性心脏病的婴儿以及15名因非心脏诊断或问题而接受脑电图检查的婴儿的脑电图进行了盲法比较。HLHS婴儿的脑电图显示安静睡眠显著减少，不确定睡眠增加，在主动睡眠和不确定睡眠中出现异常的不连续波形，且对刺激无反应。主动睡眠量、尖波、局灶性减慢或节律性θ活动方面无显著差异。这些独特的异常与记录时的动脉血气或前列腺素E治疗无关。对4名HLHS婴儿进行了重复记录；所有患者的安静睡眠均有系列性增加，不确定睡眠减少，连续性改善。某些脑电图异常在HLHS婴儿中比在其他心脏缺陷或非心脏问题患者中更频繁出现。这些发现可能是由于心力衰竭的早期发作以及升主动脉和大动脉发育不全导致的异常脑灌注所致，这些情况通常与HLHS相关。
