蠕虫领域中的抵抗素样分子（RELMs）
RELMs in the Realm of Helminths.
作者信息
Horsnell William G C, Dewals Benjamin G
机构信息
Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Fundamental and Applied Research for Animal and Health (FARAH), Immunology-Vaccinology, University of Liege, Liege, Belgium.
出版信息
Trends Parasitol. 2016 Jul;32(7):512-514. doi: 10.1016/j.pt.2016.04.011. Epub 2016 Apr 27.
Resistin-like molecule (RELM) proteins are essential for immunity to helminths. Recently, Chen and collaborators identified a dominant role for RELMα over RELMβ in host immunity to Nippostrongylus brasiliensis using a double knockout system. The study highlighted how important and yet divergent the contributions of these proteins are in the control of helminth infections.
抵抗素样分子（RELM）蛋白对抵抗蠕虫感染至关重要。最近，陈及其合作者利用双敲除系统确定了在宿主对巴西日圆线虫的免疫中，RELMα比RELMβ发挥着更主要的作用。该研究凸显了这些蛋白在控制蠕虫感染方面的贡献是多么重要且存在差异。
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