Craig J M, Scott A L
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Parasite Immunol. 2014 Sep;36(9):463-74. doi: 10.1111/pim.12102.
Parasitic helminths infect well over one billion people and typically cause chronic and recurrent infections that exert a considerable toll on human health and productivity. A significant number of important intestinal- and tissue-dwelling helminth parasites have evolved a scripted migration through select organ systems. Of specific interest here are the helminth parasites that interact with respiratory tissues and the pulmonary immune system. This review will consider the nature of the interactions between helminth parasites and the lung environment, as well as the consequences of these interactions on the evolution of parasitism and host immunity.
寄生性蠕虫感染着超过十亿人，通常会引发慢性和复发性感染，对人类健康和生产力造成相当大的损害。大量重要的肠道和组织寄生蠕虫寄生虫已经进化出通过特定器官系统的特定迁移方式。这里特别感兴趣的是与呼吸组织和肺部免疫系统相互作用的蠕虫寄生虫。本综述将探讨蠕虫寄生虫与肺部环境之间相互作用的性质，以及这些相互作用对寄生虫进化和宿主免疫的影响。
