评估血液中内源性乙醇对酗酒者及其亲属的诊断和预后意义的尝试。

An attempt to evaluate diagnostic and prognostic significance of blood endogenous ethanol in alcoholics and their relatives.

作者信息

Ostrovsky Y M, Pronko P S, Shishkin S N, Kolesnikov V B, Volynets S I

机构信息

Institute of Biochemistry, Byelorussian SSR Academy of Sciences, Grodno, USSR.

出版信息

Alcohol. 1989 Mar-Apr;6(2):97-102. doi: 10.1016/0741-8329(89)90032-3.

DOI:10.1016/0741-8329(89)90032-3

PMID:2713093

Abstract

Endogenous ethanol in the blood of human subjects was measured by gas chromatography. In healthy males, 12-13-year-old boys (sons of alcoholic and nonalcoholic fathers), and alcoholic inpatients (after cessation of all drugs), the endogenous ethanol levels ranged from 0 to 4.3 mg/l. The results showed no significant differences between the groups. At the period of alcohol withdrawal reactions the concentrations of endogenous ethanol were minimal in patients with delirium tremens and maximal in patients with mild alcohol withdrawal syndrome, the dynamics of this parameter being dependent on the severity of the alcohol withdrawal syndrome and the nature of the drugs prescribed.

摘要

采用气相色谱法测定人体受试者血液中的内源性乙醇。在健康男性、12 - 13岁男孩（酗酒和非酗酒父亲的儿子）以及酒精性疾病住院患者（停止使用所有药物后）中，内源性乙醇水平在0至4.3毫克/升之间。结果显示，各组之间无显著差异。在戒酒反应期，震颤谵妄患者的内源性乙醇浓度最低，轻度戒酒综合征患者的浓度最高，该参数的动态变化取决于戒酒综合征的严重程度和所开药物的性质。