苯甲酸钠未能减轻大鼠血浆和肝脏中的氨含量。

Failure of sodium benzoate to alleviate plasma and liver ammonia in rats.

作者信息

Palekar A G, Canas J A, Kalbag S S, Kim S J, Castro-Magana M, Angulo M A

机构信息

Department of Pediatrics, Nassau County Medical Center, State University of New York Stony Brook Health Sciences Center, East Meadow 11554.

出版信息

Biochem Med Metab Biol. 1989 Feb;41(1):64-9. doi: 10.1016/0885-4505(89)90009-1.

DOI:10.1016/0885-4505(89)90009-1

PMID:2713151

Abstract

The intraperitoneal administration of L-norvaline and L-methionine-SR-sulfoximine to rats caused an increase in the concentration of ammonia in plasma as well as in liver. These compounds interfere with urea and glutamine formation, respectively. Subsequent injection of sodium benzoate failed to alleviate ammonia levels, and on the contrary, caused a further increase. Sodium benzoate itself, when administered, resulted in higher levels of ammonia in plasma and liver of the rats. Administration of glycine to rats treated with benzoate did not lower ammonia levels indicating that other factors besides glycine may also be necessary for the removal of sodium benzoate.

摘要

给大鼠腹腔注射L-正缬氨酸和L-蛋氨酸-SR-亚砜亚胺会导致血浆和肝脏中氨的浓度升高。这些化合物分别干扰尿素和谷氨酰胺的形成。随后注射苯甲酸钠未能降低氨水平，相反，导致氨水平进一步升高。苯甲酸钠本身给药后，会使大鼠血浆和肝脏中的氨水平升高。给用苯甲酸盐处理的大鼠施用甘氨酸并不能降低氨水平，这表明除甘氨酸外，可能还需要其他因素来清除苯甲酸钠。