O'Connor J E, Costell M, Grisolía S
Biochem Biophys Res Commun. 1987 Jun 15;145(2):817-24. doi: 10.1016/0006-291x(87)91038-2.
Sodium benzoate has been recommended and even been used for the treatment of hyperammonemia in humans. More recently, a note of caution was raised since it has been shown that in experimental animals, sodium benzoate potentiates ammonia toxicity and inhibits urea synthesis in vitro. This has been further confirmed in the work presented here and the mechanism by which benzoate increases mortality and the levels of blood ammonia in mice given ammonium acetate have also been studied. In hyperammonemia, urea production and N-acetylglutamate levels were decreased by sodium benzoate. Pretreatment of mice with L-carnitine suppressed mortality following ammonium acetate plus sodium benzoate administration. Under these conditions L-carnitine lowered blood ammonia and increased urea production and N-acetylglutamate levels.
苯甲酸钠已被推荐甚至用于治疗人类的高氨血症。最近，有人提出了警示，因为研究表明，在实验动物中，苯甲酸钠会增强氨的毒性，并在体外抑制尿素合成。本研究进一步证实了这一点，并且还研究了苯甲酸钠增加给予乙酸铵的小鼠死亡率和血氨水平的机制。在高氨血症中，苯甲酸钠会降低尿素生成和N-乙酰谷氨酸水平。用L-肉碱预处理小鼠可抑制给予乙酸铵加苯甲酸钠后的死亡率。在这些条件下，L-肉碱可降低血氨水平，增加尿素生成和N-乙酰谷氨酸水平。
