成年斑马鱼和新生小鼠对心脏内源性再生理解的最新进展。
Recent advancements in understanding endogenous heart regeneration-insights from adult zebrafish and neonatal mice.
作者信息
Rubin Nicole, Harrison Michael R, Krainock Michael, Kim Richard, Lien Ching-Ling
机构信息
Heart Institute and Program of Developmental Biology and Regenerative Medicine, The Saban Research Institute of Children's Hospital Los Angeles, United States; Division of Cardiothoracic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, United States.
Heart Institute and Program of Developmental Biology and Regenerative Medicine, The Saban Research Institute of Children's Hospital Los Angeles, United States; Division of Cardiothoracic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, United States; Department of Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, United States.
出版信息
Semin Cell Dev Biol. 2016 Oct;58:34-40. doi: 10.1016/j.semcdb.2016.04.011. Epub 2016 Apr 27.
Enhancing the endogenous regenerative capacity of the mammalian heart is a promising strategy that can lead to potential treatment of injured cardiac tissues. Studies on heart regeneration in zebrafish and neonatal mice have shown that cardiomyocyte proliferation is essential for replenishing myocardium. We will review recent advancements that have demonstrated the importance of Neuregulin 1/ErbB2 and innervation in regulating cardiomyocyte proliferation using both adult zebrafish and neonatal mouse heart regeneration models. Emerging findings suggest that different populations of macrophages and inflammation might contribute to regenerative versus fibrotic responses. Finally, we will discuss variation in the severity of the cardiac injury and size of the wound, which may explain the range of outcomes observed in different injury models.
增强哺乳动物心脏的内源性再生能力是一种很有前景的策略，有望用于治疗受损的心脏组织。对斑马鱼和新生小鼠心脏再生的研究表明，心肌细胞增殖对于补充心肌至关重要。我们将回顾近期的进展，这些进展利用成年斑马鱼和新生小鼠心脏再生模型，证明了神经调节蛋白1/表皮生长因子受体2（Neuregulin 1/ErbB2）和神经支配在调节心肌细胞增殖中的重要性。新出现的研究结果表明，不同类型的巨噬细胞和炎症可能会导致再生反应与纤维化反应。最后，我们将讨论心脏损伤严重程度和伤口大小的差异，这可能解释了在不同损伤模型中观察到的结果范围。
Zotero 插件