Castillo-Casas Juan Manuel, Caño-Carrillo Sheila, Sánchez-Fernández Cristina, Franco Diego, Lozano-Velasco Estefanía
Cardiovascular Development Group, Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain.
Medina Foundation, 18007 Granada, Spain.
J Cardiovasc Dev Dis. 2023 Jul 31;10(8):325. doi: 10.3390/jcdd10080325.
Cardiovascular diseases are the leading cause of death worldwide, among which, ischemic heart disease is the most prevalent. Myocardial infarction results from occlusion of a coronary artery, which leads to an insufficient blood supply to the myocardium. As is well known, the massive loss of cardiomyocytes cannot be solved due the limited regenerative ability of the adult mammalian heart. In contrast, some lower vertebrate species can regenerate the heart after injury; their study has disclosed some of the involved cell types, molecular mechanisms and signaling pathways during the regenerative process. In this two-part review, we discuss the current state of the principal response in heart regeneration, where several involved processes are essential for full cardiac function in recovery.
心血管疾病是全球主要的死亡原因，其中缺血性心脏病最为普遍。心肌梗死是由冠状动脉阻塞导致心肌供血不足引起的。众所周知，由于成年哺乳动物心脏的再生能力有限，心肌细胞的大量损失无法得到解决。相比之下，一些低等脊椎动物物种在心脏受伤后能够再生；对它们的研究揭示了再生过程中一些涉及的细胞类型、分子机制和信号通路。在这篇分两部分的综述中，我们讨论了心脏再生主要反应的当前状态，其中几个涉及的过程对于恢复心脏的完整功能至关重要。
