通过斑马鱼和哺乳动物中的保守机制实现心脏再生的路线图。
A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals.
机构信息
Division of Cardiology, Department of Medicine, Duke University Medical Center, Box 102152, Durham, NC, 27710, USA.
Regeneration Next, Durham, NC, USA.
出版信息
Curr Cardiol Rep. 2021 Mar 2;23(4):29. doi: 10.1007/s11886-021-01459-6.
PURPOSE OF REVIEW
The replenishment of lost or damaged myocardium has the potential to reverse heart failure, making heart regeneration a goal for cardiovascular medicine. Unlike adult mammals, injury to the zebrafish or neonatal mouse heart induces a robust regenerative program with minimal scarring. Recent insights into the cellular and molecular mechanisms of heart regeneration suggest that the machinery for regeneration is conserved from zebrafish to mammals. Here, we will review conserved mechanisms of heart regeneration and their translational implications.
RECENT FINDINGS
Based on studies in zebrafish and neonatal mice, cardiomyocyte proliferation has emerged as a primary strategy for effecting regeneration in the adult mammalian heart. Recent work has revealed pathways for stimulating cardiomyocyte cell cycle reentry; potential developmental barriers for cardiomyocyte proliferation; and the critical role of additional cell types to support heart regeneration. Studies in zebrafish and neonatal mice have established a template for heart regeneration. Continued comparative work has the potential to inform the translation of regenerative biology into therapeutics.
目的综述：补充丢失或受损的心肌有逆转心力衰竭的潜力，使心脏再生成为心血管医学的一个目标。与成年哺乳动物不同，斑马鱼或新生小鼠的心脏损伤会引发强大的再生程序，几乎没有疤痕。最近对心脏再生的细胞和分子机制的深入了解表明，从斑马鱼到哺乳动物，再生的机制是保守的。在这里，我们将回顾心脏再生的保守机制及其转化意义。
最近的发现：基于对斑马鱼和新生小鼠的研究，心肌细胞增殖已成为成年哺乳动物心脏实现再生的主要策略。最近的工作揭示了刺激心肌细胞细胞周期再进入的途径；心肌细胞增殖的潜在发育障碍；以及其他细胞类型支持心脏再生的关键作用。斑马鱼和新生小鼠的研究为心脏再生建立了一个模板。持续的比较研究有可能将再生生物学转化为治疗方法。
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