Lynch H T, Marcus J N, Weisenburger D D, Watson P, Fitzsimmons M L, Grierson H, Smith D M, Lynch J, Purtilo D
Department of Preventive Medicine/Public Health, Creighton University School of Medicine, Omaha, NE 68178.
Br J Cancer. 1989 Apr;59(4):622-6. doi: 10.1038/bjc.1989.126.
We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin's lymphoma, while a granddaughter had Hodgkin's disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3 level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.
我们研究了一个非凡的家族,该家族三代中有7例恶性淋巴瘤患者,其中5名姐妹及其母亲经组织病理学证实患有非霍奇金淋巴瘤,而一名孙女患有霍奇金病。我们对3名淋巴瘤幸存者、9名他们的一级亲属以及4名配偶对照进行了免疫学研究。显著发现包括9名一级亲属中有4人血清IgG3水平降低;在这4人中,有2人对商陆有丝分裂原和刀豆球蛋白A的淋巴细胞刺激反应显著降低。该家族中存在的细微免疫异常可能与淋巴瘤的发病机制有关。