一级亲属中的非霍奇金恶性淋巴瘤和霍奇金病。存在共同遗传易感性的证据？

Non-Hodgkin malignant lymphomas and Hodgkin's disease in first-degree relatives. Evidence for a mutual genetic predisposition?

作者信息

Bjerrum O W, Hasselbalch H C, Drivsholm A, Nissen N I

出版信息

Scand J Haematol. 1986 Apr;36(4):398-401. doi: 10.1111/j.1600-0609.1986.tb01756.x.

DOI:10.1111/j.1600-0609.1986.tb01756.x

Abstract

The occurrence of malignant lymphomas in 3 siblings is described. The cases include the first report of Hodgkin's disease and non-Hodgkin malignant lymphoma in dizygotic twins. Another remarkable feature was the development of malignant lymphoma, when the siblings were at the same age. Although a transmissible agent or environmental factors cannot be excluded in this family, our observations may suggest a mutual genetic predisposition in Hodgkin's disease and non-Hodgkin malignant lymphoma.

摘要

本文描述了3名兄弟姐妹患恶性淋巴瘤的情况。这些病例包括双卵双胞胎中霍奇金病和非霍奇金恶性淋巴瘤的首例报告。另一个显著特征是，这些兄弟姐妹在相同年龄时患上了恶性淋巴瘤。虽然不能排除该家族中存在可传播因子或环境因素，但我们的观察结果可能提示霍奇金病和非霍奇金恶性淋巴瘤存在共同的遗传易感性。