Ashworth J, Tuyp E, Mackie R M
University Department of Dermatology, Western Infirmary, Glasgow, U.K.
Br J Dermatol. 1989 Mar;120(3):397-401. doi: 10.1111/j.1365-2133.1989.tb04166.x.
Diphencyprone is a potent topical sensitizer, but is non-mutagenic in the Ames test (unlike dinitroclorobenzene) and remains relatively stable in solution (unlike squaric acid dibutyl ester). Seventeen patients with total loss of scalp hair (eight alopecia totalis, nine alopecia universalis) were treated by maintaining on one side of the scalp an allergic contact dermatitis induced by 2,3 diphenylcyclopropenone-I ('diphencyprone'), and on the other side an irritant contact dermatitis using tretinoin gel (Retin A). After 20 weeks, treatment with tretinoin was stopped and diphencyprone was applied bilaterally for a further 10 weeks. Satisfactory regrowth of terminal hair on the scalp was achieved in only one patient. Eyebrow, eyelash and beard regrowth was achieved in one individual whilst in another, moderate, but not cosmetically satisfactory, scalp regrowth took place. In no patient did regrowth take place at tretinoin treated sites until after diphencyprone was substituted.
二苯环丙烯酮是一种强效的局部致敏剂，但在艾姆斯试验中无致突变性（与二硝基氯苯不同），并且在溶液中相对稳定（与二丁基环丙烷四羧酸酯不同）。17例头皮毛发完全脱落的患者（8例全秃，9例普秃）接受了如下治疗：在头皮一侧通过使用2,3 - 二苯基环丙烯酮 - I（“二苯环丙烯酮”）诱发过敏性接触性皮炎，在另一侧使用维甲酸凝胶（维甲酸）诱发刺激性接触性皮炎。20周后，停止使用维甲酸治疗，双侧应用二苯环丙烯酮再治疗10周。仅1例患者头皮上的终毛实现了满意的再生。1例患者实现了眉毛、睫毛和胡须的再生，而另1例患者头皮有中度再生，但美容效果不令人满意。在二苯环丙烯酮替代维甲酸治疗之前，在维甲酸治疗部位均未出现再生情况。
