van der Steen P H, van Baar H M, Perret C M, Happle R
Department of Dermatology, University of Nijmegen, The Netherlands.
J Am Acad Dermatol. 1991 Feb;24(2 Pt 1):253-7. doi: 10.1016/0190-9622(91)70037-3.
One hundred thirty-nine patients with severe alopecia areata (the majority with the subtotal, total, or universalis type) were treated with topical immunotherapy (diphenylcyclopropenone). Patients were initially treated unilaterally; the other side of the scalp served as a control. In 50.4% of the patients the response was either excellent (total regrowth) or satisfactory (subtotal regrowth with only a few remaining bald patches). The most frequent side effects were eczematous reactions with blistering, spreading of the induced contact eczema, and sleep disturbances.
