Rives-Lange C, Karsenty A, Chantereau H, Oderda L, Dubern B, Lecendreux M, Tounian P
Service de nutrition et gastro-entérologie pédiatriques, hôpital Trousseau, AP-HP, université Paris 6, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France.
Service de nutrition et gastro-entérologie pédiatriques, hôpital Trousseau, AP-HP, université Paris 6, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France.
Arch Pediatr. 2016 Jun;23(6):603-6. doi: 10.1016/j.arcped.2016.03.012. Epub 2016 Apr 25.
Narcolepsy is a disabling disorder, characterized by excessive daytime sleepiness, irresistible sleep attacks, and partial or complete cataplexy. Many cases of obesity and precocious puberty have been reported in narcoleptic children, suggesting that the deficiency of hypocretin in narcolepsy could also be implicated in appetite stimulation. We report the observations of two young girls, who were referred for obesity and who developed narcolepsy accompanied by an abrupt weight gain. In both cases, specific drugs promoted wakefulness and overweight stabilization. Narcolepsy has to be suspected in sleepy obese children and not misdiagnosed as obstructive apnea. A nocturnal polysomnography with multiple sleep latency tests should be performed to confirm the diagnosis and begin specific treatment that is effective for sleep disorders and weight gain.
发作性睡病是一种致残性疾病，其特征为日间过度嗜睡、不可抗拒的睡眠发作以及部分或完全性猝倒。发作性睡病患儿中已有许多肥胖和性早熟病例的报道，这表明发作性睡病中下丘脑分泌素的缺乏也可能与食欲刺激有关。我们报告了两名年轻女孩的观察结果，她们因肥胖前来就诊，随后患上了发作性睡病并伴有体重突然增加。在这两个病例中，特定药物促进了清醒并使体重稳定。对于嗜睡的肥胖儿童，必须怀疑发作性睡病，而不能误诊为阻塞性睡眠呼吸暂停。应进行夜间多导睡眠图检查及多次睡眠潜伏期试验，以确诊并开始针对睡眠障碍和体重增加有效的特异性治疗。
