Hahn Barry, Bonhomme Keisha, Finnie Jamecia, Adwar Sean, Lesser Martin, Hirschorn David
Department of Emergency Medicine, Staten Island University Hospital, Staten Island, NY.
Department of Emergency Medicine, Staten Island University Hospital, Staten Island, NY.
Clin Imaging. 2016 May-Jun;40(3):398-401. doi: 10.1016/j.clinimag.2015.11.021. Epub 2015 Dec 3.
Abdominal aortic aneurysm (AAA) development is a multifactorial process that is more prevalent among people ≥65years of age. Major risk factors are obesity, male sex, history of smoking (at least 100 cigarettes in a person's lifetime), and history of AAA in a first-degree relative. The United States Preventative Task Force has recommended a one-time ultrasound screening for men aged 65-75years. Based on studies, negative results on a single ultrasound examination around the age of 65years appear to virtually exclude the risk for future AAA rupture or death. While ultrasonography (US) is the confirmatory study of choice, computed tomography (CT) can also be used in the diagnosis of AAA. The goal of this study is to determine if AAA rupture can reliably be excluded in individuals with abdominal pain who have had a normal caliber aorta on CT or US after the age of 65years.
A retrospective study (approved by institutional review board) of emergency department (ED) patients in an urban academic center was performed. Subjects were included if they met the following criteria: age ≥65years; an initial CT or US as an ED patient, inpatient, or outpatient for any indication, which identified an abdominal aorta <3cm; and a second CT or US during an ED visit. The incidence of ruptured AAA on the second CT or US with a history of normal aortic caliber was identified.
During the study period, 606 subjects were enrolled. Demographic data are listed in Table 1. Three subjects (0.5%) exhibited an abnormal-sized aorta on ED evaluation. None of these three subjects had an AAA intervention. The average size of the abnormal aorta in these three subjects was 3.3cm (S.D. 0.17).
Based on these results, it appears that AAA and rupture may reliably be excluded in ED patients with abdominal pain who have previously had a normal caliber aorta on CT or US after the age of 65years. A prospective, multicenter study would help validate these findings.
腹主动脉瘤(AAA)的发展是一个多因素过程,在65岁及以上人群中更为普遍。主要风险因素包括肥胖、男性、吸烟史(一生中至少100支香烟)以及一级亲属中有AAA病史。美国预防服务工作组建议对65至75岁的男性进行一次性超声筛查。根据研究,65岁左右单次超声检查结果为阴性似乎实际上排除了未来AAA破裂或死亡的风险。虽然超声检查(US)是首选的确诊研究,但计算机断层扫描(CT)也可用于AAA的诊断。本研究的目的是确定在65岁以后CT或US显示主动脉管径正常的腹痛患者中,是否可以可靠地排除AAA破裂的可能性。
对一家城市学术中心急诊科(ED)患者进行了一项回顾性研究(经机构审查委员会批准)。符合以下标准的受试者被纳入研究:年龄≥65岁;作为ED患者、住院患者或门诊患者因任何指征进行的首次CT或US检查,显示腹主动脉<3cm;以及在ED就诊期间进行的第二次CT或US检查。确定第二次CT或US检查时主动脉管径正常但有AAA破裂的发生率。
在研究期间,共纳入606名受试者。人口统计学数据列于表1。三名受试者(0.5%)在ED评估时显示主动脉大小异常。这三名受试者均未接受AAA干预。这三名受试者异常主动脉的平均大小为3.3cm(标准差0.17)。
基于这些结果,似乎在65岁以后CT或US显示主动脉管径正常的腹痛ED患者中,可以可靠地排除AAA及其破裂的可能性。一项前瞻性、多中心研究将有助于验证这些发现。