Donatsky O, Justesen T, Lind K, Vestergaard B F
Scand J Dent Res. 1977 Sep;85(6):426-33. doi: 10.1111/j.1600-0722.1977.tb00576.x.
Qualitative and quantitative examinations of the cultivable bacterial flora in biopsies from recurrent aphthous ulcerations (RAU), experimental oral ulcerations (EOU), and normal oral mucosa (NOM) were carried out under aerobic and continuous anaerobic conditions. An attempt was made to culture yeasts, mycoplasma, and virus from the biopsies of RAU, which were also tested for the presence of herpes virus antigen by the fluorescent antibody method. The predominant bacteria recovered in RAU were alpha-hemolytic streptococci, coagulase-negative staphylococci, and Neisseria. In EOU the main recoveries were alpha-hemolytic streptococci, Corynebacterium, Veillonella, Neisseria, and Haemophilus. In NOM alpha-hemolytic streptococci dominated the cultures. Yeasts were only cultured from one patient with RAU. No mycoplasmas or viruses were isolated, nor was herpes virus antigen demonstrated in any of the RAU specimens. The role of the microorganisms in the pathogenesis of RAU is discussed.
在需氧和持续厌氧条件下，对复发性阿弗他溃疡（RAU）、实验性口腔溃疡（EOU）和正常口腔黏膜（NOM）活检组织中可培养细菌菌群进行了定性和定量检测。尝试从RAU活检组织中培养酵母菌、支原体和病毒，并用荧光抗体法检测RAU活检组织中疱疹病毒抗原的存在。RAU中分离出的主要细菌为甲型溶血性链球菌、凝固酶阴性葡萄球菌和奈瑟菌。EOU中主要分离出的细菌为甲型溶血性链球菌、棒状杆菌、韦荣球菌、奈瑟菌和嗜血杆菌。NOM培养物中以甲型溶血性链球菌为主。仅从1例RAU患者中培养出酵母菌。未分离出支原体或病毒，且在任何RAU标本中均未检测到疱疹病毒抗原。文中讨论了微生物在RAU发病机制中的作用。
