Lee Chanwoo, Kwon Taekmin, Yoo Sangjun, Jung Jaeyoon, Lee Chunwoo, You Dalsan, Jeong In Gab, Kim Choung-Soo
Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea .
Department of Urology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea .
J Korean Med Sci. 2016 May;31(5):743-9. doi: 10.3346/jkms.2016.31.5.743. Epub 2016 Mar 18.
We compared postoperative renal function impairment between patients undergoing robot-assisted partial nephrectomy (RAPN) and those undergoing open partial nephrectomy (OPN) by using Tc-99m diethylenetriaminepentaacetic acid (DTPA) renal scintigraphy. Patients who underwent partial nephrectomy by a single surgeon between 2007 and 2013 were eligible and were matched by propensity score, based on age, tumor size, exophytic properties of tumor, and location relative to the polar lines. Of the 403 patients who underwent partial nephrectomy, 114 (28%) underwent RAPN and 289 (72%) underwent OPN. Mean follow-up duration was 35.2 months. Following propensity matching, there were no significant differences between the two groups in tumor exophytic properties (P = 0.818) or nephrometry score (P = 0.527). Renal ischemic time (24.4 minutes vs. 17.8 minutes, P < 0.001) was significantly longer in the RAPN group than in the OPN group, while the other characteristics were similar. Multivariate analysis showed that greater preoperative renal unit function (P = 0.011) and nephrometry score (P = 0.041) were independently correlated with a reduction in glomerular filtration rate. The operative method did not correlate with renal function impairment (P = 0.704). Postoperative renal function impairment was similar between patients who underwent OPN and those who underwent RAPN, despite RAPN having a longer ischemic time.
我们通过使用锝-99m二乙三胺五乙酸(DTPA)肾闪烁显像术,比较了接受机器人辅助部分肾切除术(RAPN)的患者与接受开放性部分肾切除术(OPN)的患者术后肾功能损害情况。2007年至2013年间由单一外科医生进行部分肾切除术的患者符合条件,并根据年龄、肿瘤大小、肿瘤的外生性特征以及相对于极线的位置进行倾向评分匹配。在接受部分肾切除术的403例患者中,114例(28%)接受了RAPN,289例(72%)接受了OPN。平均随访时间为35.2个月。倾向匹配后,两组在肿瘤外生性特征(P = 0.818)或肾计量评分(P = 0.527)方面无显著差异。RAPN组的肾缺血时间(24.4分钟对17.8分钟,P < 0.001)明显长于OPN组,而其他特征相似。多因素分析显示,术前肾功能单位功能较好(P = 0.011)和肾计量评分较高(P = 0.041)与肾小球滤过率降低独立相关。手术方式与肾功能损害无关(P = 0.704)。尽管RAPN组缺血时间较长,但接受OPN的患者与接受RAPN的患者术后肾功能损害相似。