Kryzhanovskiĭ G N, Karganov M Iu, Shandra A A, Godlevskiĭ L S, Lutsenko V K
Biull Eksp Biol Med. 1989 Mar;107(3):271-4.
The pharmacological kindling was induced in rats by corazol repeated injections in subthreshold doses. The peptide-containing fraction was emitted from animal brains by the help of hot acetic acid on the stage of generalized clonic-tonic seizures development. Intraperitoneal injection of brain extracts of kindled rats significantly increased corazol and picrotoxin induced seizure severity in mice. The effect was removed by preliminary injection of naloxone or by preventive incubation of extracts with pronase. Intraventricular injection of extracts to intact rats increased the seizure severity which was provoked by corazol and in high doses induced in rats generalized seizure reactions.
通过对大鼠重复注射阈下剂量的戊四氮来诱导药物点燃效应。在全身性阵挛 - 强直发作发展阶段，借助热乙酸从动物大脑中提取含肽部分。腹腔注射点燃大鼠的脑提取物可显著增加戊四氮和印防己毒素诱导的小鼠癫痫发作严重程度。预先注射纳洛酮或用链霉蛋白酶对提取物进行预防性孵育可消除该效应。向未处理的大鼠脑室内注射提取物会增加戊四氮诱发的癫痫发作严重程度，且高剂量时会在大鼠中诱发全身性癫痫反应。
