Gustavsson A, Mitelman F, Olsson I
Scand J Haematol. 1977 Nov;19(5):449-52. doi: 10.1111/j.1600-0609.1977.tb01500.x.
A case report of serial chromosome studies on a 26-year-old male with acute myeloid leukaemia (AML) is presented. The classic Philadelphia chromosome (Ph1) translocation, t (9;22) was found in 77% of the metaphases at diagnosis and in 100% in relapse; during a 3-month remission period the cytogenetic picture was normal or the Ph1 was present in a minor cell population only. The clinical and morphologic features of this case indicated that it was really a case of AML and less likely chronic myeloid leukaemia (CML) presenting in blast crisis. It is suggested that the oncogen producing the 9;22-translocation and CML may also induce AML in rare instances.
本文报告了对一名26岁急性髓细胞白血病（AML）男性患者进行系列染色体研究的病例。经典的费城染色体（Ph1）易位，即t（9；22），在诊断时77%的中期相中被发现，复发时则为100%；在3个月的缓解期，细胞遗传学表现正常，或仅在少数细胞群体中存在Ph1。该病例的临床和形态学特征表明，这确实是一例AML，而非慢性髓细胞白血病（CML）急变期。提示产生9；22易位和CML的致癌基因在罕见情况下也可能诱发AML。
