Chen Xing, Zou Liqiang, Liu Wei, McClements David Julian
State Key Laboratory of Food Science and Technology, Nanchang University , No. 235 Nanjing East Road, Nanchang 330047, Jiangxi China.
Department of Food Science, University of Massachusetts , Amherst, Massachusetts 01003, United States.
J Agric Food Chem. 2016 May 11;64(18):3653-60. doi: 10.1021/acs.jafc.6b01056. Epub 2016 May 2.
The potential for excipient emulsions to enhance the bioaccessibility and antioxidant activity of quercetin was determined in this study. Oil-in-water excipient emulsions containing two levels (4 or 10%) of small lipid droplets (d < 250 nm) were prepared from a long-chain triglyceride (corn oil). The solubilization of quercetin by the excipient emulsions was faster than by bulk corn oil or bulk water, and the solubilization rate was higher at 100 °C than at 30 °C. The bioaccessibility of quercetin samples was determined using an in vitro gastrointestinal model, and the bioactivity of quercetin was determined using a rat feeding study. The excipient emulsions were more effective at enhancing quercetin bioaccessibility and rat plasma antioxidant activity than either bulk oil or bulk water. This effect was attributed to the rapid digestion of the long chain triglycerides when they were in an emulsified form, which led to the rapid production of mixed micelles capable of solubilizing, protecting, and transporting quercetin.
本研究测定了辅料乳液提高槲皮素生物可及性和抗氧化活性的潜力。由长链甘油三酯（玉米油）制备了含有两种小脂滴水平（4%或10%）（直径<250nm）的水包油型辅料乳液。槲皮素在辅料乳液中的溶解速度比在玉米油本体或水中更快，且在100℃时的溶解速度高于30℃。使用体外胃肠道模型测定槲皮素样品的生物可及性，并通过大鼠喂养研究测定槲皮素的生物活性。辅料乳液在提高槲皮素生物可及性和大鼠血浆抗氧化活性方面比玉米油本体或水更有效。这种作用归因于长链甘油三酯以乳化形式时的快速消化，这导致能够溶解、保护和转运槲皮素的混合微团快速产生。
