Department of Organic Chemistry, Weizmann Institute of Science , Rehovot 76100, Israel.
J Am Chem Soc. 2016 May 18;138(19):6143-6. doi: 10.1021/jacs.6b03488. Epub 2016 May 10.
An atom-economical and environmentally friendly method to transform amino alcohols to amino acid salts using just basic water, without the need of pre-protection or added oxidant, catalyzed by a ruthenium pincer complex, is developed. Water is the solvent, the source of the oxygen atom of the carboxylic acid group, and the actual oxidant, with liberation of dihydrogen. Many important and useful natural and unnatural amino acid salts can be produced in excellent yields by applying this new method.
开发了一种原子经济性且环境友好的方法，使用碱性水，无需预保护或添加氧化剂，在钌钳形配合物的催化下，将氨基醇转化为氨基酸盐。水既是溶剂，也是羧酸基团中氧原子的来源，也是实际的氧化剂，同时释放氢气。通过应用这种新方法，可以以优异的收率得到许多重要和有用的天然和非天然氨基酸盐。
