由二炔酮和水进行4-吡喃酮的原子经济性合成
Atom-Economic Synthesis of 4-Pyrones from Diynones and Water.
作者信息
Xu Yan-Li, Teng Qing-Hu, Tong Wei, Wang Heng-Shan, Pan Ying-Ming, Ma Xian-Li
机构信息
College of Pharmacy, Guilin Medical University, Guilin 541004, China.
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China.
出版信息
Molecules. 2017 Jan 10;22(1):109. doi: 10.3390/molecules22010109.
Transition-metal-free synthesis of 4-pyrones via TfOH-promoted nucleophilic addition/cyclization of diynones and water has been developed. This transformation is simple, atom economical and environmentally benign, providing rapid and efficient access to substituted 4-pyrones.
通过三氟甲磺酸（TfOH）促进的二炔酮与水的亲核加成/环化反应，实现了无过渡金属合成4-吡喃酮。该转化反应简单、原子经济性高且环境友好，能快速高效地合成取代的4-吡喃酮。
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