Saroglou G, Bisno A L
Antimicrob Agents Chemother. 1978 Apr;13(4):701-2. doi: 10.1128/AAC.13.4.701.
The minimal inhibitory concentrations of rosamicin and erythromycin were compared for 210 strains of group A streptococcus isolated from a diverse spectrum of streptococcal diseases. Of these strains, 97.6% were inhibited by 0.1 to 0.2 mug of rosamicin per ml, whereas 90.9% were inhibited by 0.025 to 0.05 mug of erythromycin per ml. The minimal inhibitory concentration of rosamicin for 154 strains exceeded that of erythromycin by at least fourfold. Five group A strains of streptococcus that were highly resistant to erythromycin were even more resistant to rosamicin.
对从多种链球菌疾病中分离出的210株A组链球菌，比较了罗沙米星和红霉素的最低抑菌浓度。在这些菌株中，97.6%的菌株被每毫升0.1至0.2微克的罗沙米星抑制，而90.9%的菌株被每毫升0.025至0.05微克的红霉素抑制。154株菌株的罗沙米星最低抑菌浓度比红霉素至少高四倍。五株对红霉素高度耐药的A组链球菌菌株对罗沙米星的耐药性更强。
