Drapkin M S, Karchmer A W, Moellering R C
JAMA. 1976 Jul 19;236(3):263-5.
We have recently observed four patients with bacteremic infections due to group A streptococci that were highly resistant to clindamycin and only moderately susceptible to erythromycin. Two of the infections developed while the patients were receiving clindamycin. The organisms were not beta-hemolytic under standard conditions nor were they M or T typable. We urge that all streptococci isolated from patients with serious infections be grouped serologically and be tested for antibiotic susceptibilities, especially if therapy with antibiotics other than penicillin is to be considered.
我们最近观察到4例由A组链球菌引起的菌血症感染患者，这些菌株对克林霉素高度耐药，对红霉素仅中度敏感。其中2例感染是在患者接受克林霉素治疗时发生的。这些菌株在标准条件下不是β溶血性的，也无法进行M或T分型。我们敦促，从严重感染患者中分离出的所有链球菌都应进行血清学分组并检测抗生素敏感性，尤其是在考虑使用青霉素以外的抗生素进行治疗时。
