Zemlin Annalise E, Matsha Tandi E, Kengne Andre P, Hon Gloudina M, Erasmus Rajiv T
1 Division of Chemical Pathology, Faculty of Health Sciences, National Health Laboratory Service (NHLS) and Stellenbosch University, Cape Town, South Africa.
2 Department of Biomedical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town, South Africa.
Ann Clin Biochem. 2017 Jan;54(1):92-100. doi: 10.1177/0004563216640001. Epub 2016 Sep 28.
Background E-selectin, an adhesion molecule, is a specific marker of endothelial dysfunction. High concentrations have been reported in type 2 diabetes and disorders with high risk of cardiovascular disease (CVD). Measurement of carotid intima-media thickness (CIMT) is a surrogate marker of early atherosclerosis. We examined the relationship between E-selectin concentrations, CIMT and cardio-metabolic traits in normo- and hyperglycaemic mixed ancestry South Africans. Methods E-selectin concentrations were determined in 308 subjects from the Cape Town Bellville South Community-based study on a mixed ancestry population. Their correlation with CIMT and cardio-metabolic profile used robust correlations and linear regression models. Results E-selectin concentrations were significantly higher in the hyperglycaemic (median 139.8 µg/L) compared to the normoglycaemic group (median 118.8 µg/L), ( p = 0.0007). Significant differences between the two groups were found for markers of glycaemia and adiposity, but not for CIMT. Significant correlations were found between E-selectin and age, markers of glycaemia and inflammation, central obesity and lipid variables. Associations remained significant only with age, hyperglycaemia and C-reactive protein in robust linear regression models. In similar regressions models, age and gender were the main predictors of CIMT, which was not associated with E-selectin. Conclusions E-selectin concentrations in this study were associated with hyperglycaemia, possibly reflecting early endothelial damage. However, E-selectin was not useful to assess CIMT, a marker of subclinical atherosclerosis, which appeared to be determined by ageing and male gender.
E-选择素是一种黏附分子，是内皮功能障碍的特异性标志物。据报道，2型糖尿病和心血管疾病（CVD）高风险疾病中E-选择素浓度较高。颈动脉内膜中层厚度（CIMT）的测量是早期动脉粥样硬化的替代标志物。我们研究了正常血糖和高血糖的南非混合血统人群中E-选择素浓度、CIMT与心脏代谢特征之间的关系。方法：在开普敦贝尔维尔南区基于社区的混合血统人群研究中，对308名受试者测定E-选择素浓度。使用稳健相关性和线性回归模型分析其与CIMT和心脏代谢特征的相关性。结果：高血糖组（中位数139.8μg/L）的E-选择素浓度显著高于正常血糖组（中位数118.8μg/L），（p = 0.0007）。两组在血糖和肥胖标志物方面存在显著差异，但在CIMT方面无显著差异。E-选择素与年龄、血糖和炎症标志物、中心性肥胖和脂质变量之间存在显著相关性。在稳健线性回归模型中，仅年龄、高血糖和C反应蛋白之间的关联仍然显著。在类似的回归模型中，年龄和性别是CIMT的主要预测因素，CIMT与E-选择素无关。结论：本研究中E-选择素浓度与高血糖相关，可能反映早期内皮损伤。然而，E-选择素对评估CIMT（亚临床动脉粥样硬化的标志物）并无帮助，CIMT似乎由年龄和男性性别决定。
