大鼠模型中氧化钛和氯化钙改性波特兰水泥的生物相容性

Biocompatibility of Portland Cement Modified with Titanium Oxide and Calcium Chloride in a Rat Model.

作者信息

Hoshyari Narjes, Labbaf Hossein, Jalayer Naderi Nooshin, Kazemi Ali, Bastami Farshid, Koopaei Maryam

机构信息

Endodontic Department, Dental School, Mazandaran University of Medical Sciences, Sari, Iran;

Endodontic Department, Dental School, Shahed University, Tehran, Iran;

出版信息

Iran Endod J. 2016 Spring;11(2):124-8. doi: 10.7508/iej.2016.02.010. Epub 2016 Mar 20.

DOI:10.7508/iej.2016.02.010

PMID:27141221

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4841348/

Abstract

INTRODUCTION

The aim of the present study was to evaluate the biocompatibility of two modified formulations of Portland cement (PC) mixed with either titanium oxide or both titanium oxide and calcium chloride.

METHODS AND MATERIALS

Polyethylene tubes were filled with modified PCs or Angelus MTA as the control; the tubes were then implanted in 28 Wistar rats subcutaneously. One tube was left empty as a negative control in each rat. Histologic samples were taken after 7, 15, 30 and 60 days. Sections were assessed histologically for inflammatory responses and presence of fibrous capsule and granulation tissue formation. Data were analyzed using the Fisher's exact and Kruskal-Wallis tests.

RESULT

PC mixed with titanium oxide showed the highest mean scores of inflammation compared with others. There was no statistically significant difference in the mean inflammatory grades between all groups in each of the understudy time intervals.

CONCLUSION

The results showed favorable biocompatibility of these modified PC mixed with calcium chloride and titanium oxide.

摘要

引言

本研究的目的是评估两种分别与氧化钛混合或与氧化钛和氯化钙混合的改性波特兰水泥（PC）配方的生物相容性。

方法和材料

将聚乙烯管填充改性PC或作为对照的Angelus MTA；然后将这些管子皮下植入28只Wistar大鼠体内。每只大鼠留一根空管作为阴性对照。在7、15、30和60天后采集组织学样本。对切片进行组织学评估，观察炎症反应以及纤维囊和肉芽组织形成情况。使用Fisher精确检验和Kruskal-Wallis检验分析数据。