Department for Biomaterials, Faculty for Dentistry, University of Oslo NO-0317 Oslo, Norway.
J Biomater Appl. 2011 Feb;25(6):559-80. doi: 10.1177/0885328209354925. Epub 2010 Jan 20.
The current study compares biocompatibility, cell growth and morphology, pore diameter distribution, and interconnectivity of a novel titanium dioxide (TiO(2)) bone graft substitute granules with three different commercially available bone graft granules Natix, Straumann BoneCeramic, and Bio-Oss. Human primary mesenchymal stem cells were cultured on the bone graft substitutes and cell viability and proliferation were evaluated after 1 and 3 days. The microstructural properties of the bone graft substitutes were evaluated by scanning electron microscopy, micro-computed tomography analysis, and mechanical testing. The cell viability and proliferation, porosity, interconnectivity, open pore size, and surface area-to-volume ratio of TiO(2) granules were significantly higher than commercial bone granules (Bio-Oss and Straumann BoneCeramic).
本研究比较了一种新型二氧化钛（TiO(2)）骨移植替代颗粒与三种不同市售骨移植颗粒（Natix、Straumann BoneCeramic 和 Bio-Oss）的生物相容性、细胞生长和形态、孔径分布和连通性。将人原代间充质干细胞培养在骨移植物上，并在第 1 天和第 3 天评估细胞活力和增殖。通过扫描电子显微镜、微计算机断层扫描分析和力学测试评估骨移植物的微观结构特性。TiO(2)颗粒的细胞活力和增殖、孔隙率、连通性、开孔径和表面积-体积比均显著高于商业骨颗粒（Bio-Oss 和 Straumann BoneCeramic）。
