[灵芝菌丝体多糖的抗肿瘤活性：体内比较研究]

[Antitumor Activity of Polysaccharides from Ganoderma lucidum Mycelium: in vivo Comparative Study].

作者信息

Krasnopolskaya L M, Yarina M S, Avtonomova A V, Usov A I, Isakova E B, Bukchman V M

出版信息

Antibiot Khimioter. 2015;60(11-12):29-34.

Abstract

Fractions of water soluble and alkali soluble polysaccharides, as well as fucogalactan, a water soluble polysaccharide, and xylomannan, an alkali soluble polysaccharide, were isolated from the Ganoderma lucidum submerged mycelium. When administered orally, the polysaccharides showed antitumor activity in vivo on murine models of solid tumors. Xylomannan and fucogalactan showed the highest antitumor activity. Sensitivity to xylomannan was more pronounced in adenocarcinoma Ca755 as compared to the T-cell lymphocytic leukemia P388. The antitumor activity of the water soluble polysaccharides total fractions from the mycelium and fruiting bodies of the G. lucidum strain was almost identical. The maximum antitumor effect of the mycelium water soluble polysaccharides total fraction was observed with the use of the daily dose of 2 mg/kg.

摘要

从灵芝深层发酵菌丝体中分离出了水溶性多糖、碱溶性多糖组分，以及一种水溶性多糖岩藻半乳聚糖和一种碱溶性多糖木糖甘露聚糖。口服给药时，这些多糖在实体瘤小鼠模型中显示出体内抗肿瘤活性。木糖甘露聚糖和岩藻半乳聚糖表现出最高的抗肿瘤活性。与T细胞淋巴细胞白血病P388相比，腺癌Ca755对木糖甘露聚糖的敏感性更为明显。灵芝菌株菌丝体和子实体的水溶性多糖总组分的抗肿瘤活性几乎相同。菌丝体水溶性多糖总组分在每日剂量为2 mg/kg时观察到最大抗肿瘤效果。