Morozova E O, Blinov M N
Vopr Med Khim. 1977 Nov-Dec(6):812-8.
Spectra of nuclear RNA were studied in leukocytes in healthy donors and in patients with leukoses by DNA-RNA hybridization. Cross competitive hybridization showed that in chronic lymphoid leukosis and acute myeloblastosis new forms of nuclear RNA were observed, which were not found in normal state; in myeloleukosis the nuclear RNA spectra were similar to those of normal granulocytes. The results obtained suggest that universal type of impairments appears to be absent in regulation of transcription in leukoses; it may be related not only to leukosis transformation but depends on variations in cell content of leukocyte populations studied.
通过DNA-RNA杂交研究了健康供体白细胞和白血病患者白细胞中的核RNA谱。交叉竞争杂交表明，在慢性淋巴细胞白血病和急性成髓细胞白血病中观察到了正常状态下未发现的新形式的核RNA；在骨髓白血病中，核RNA谱与正常粒细胞相似。所得结果表明，白血病转录调控中似乎不存在普遍类型的损伤；这可能不仅与白血病转化有关，还取决于所研究白细胞群体细胞含量的变化。
