Maj S, Sitarska E, Szczygiel M
Acta Haematol Pol. 1977 Jan-Mar;8(1):15-20.
Using the method of ion-exchange chromatography in automatic analyser the level of free amino acids was determined in peripheral blood leucocytes of 14 healthy blood donors and 36 patients with various types of leukaemia. In comparison with granulocytes the concentration of free amino acids in lymphocytes was reduced. The concentration of free amino acids in lymphocytes of chronic lymphatic leukemia was not essentially changed. The leucocytes in chronic myeloid leukemia showed a rise in the concentration of most free amino acids. In the blast cells of patients with acute myeloid the concentration of free amino acids was reduced in relation to DNA contents while in relation to proteins this concentration was raised.
采用离子交换色谱法在自动分析仪上测定了14名健康献血者和36例各类白血病患者外周血白细胞中游离氨基酸的水平。与粒细胞相比，淋巴细胞中游离氨基酸的浓度降低。慢性淋巴细胞白血病患者淋巴细胞中游离氨基酸的浓度基本未变。慢性粒细胞白血病患者的白细胞中大多数游离氨基酸的浓度升高。急性髓性白血病患者的原始细胞中，相对于DNA含量，游离氨基酸的浓度降低，而相对于蛋白质，该浓度升高。
