Kharchenko M F, Shatskaia T L, Shcherbakova E G, Abdulkadyrov K M
Vopr Onkol. 1986;32(10):47-53.
The level and composition of glycosaminoglycans (GAG) were studied in leukocytes of healthy donors and patients with different forms of leukemia. GAG level was found to increase in chronic myeloproliferative disorders. This parameter was far below the norm in most cases of acute leukemia. An evaluation of GAG profile established a relationship between cell GAG level variation, the type of proliferating cells and leukemic transformation. Peculiarities of GAG profile in myeloid and lymphoid cells were identified. It was shown that a study of GAG in leukocytes of leukemic patients may contribute to identification of blast elements and differential diagnosis between leukemia types.
对健康供者及不同类型白血病患者白细胞中的糖胺聚糖（GAG）水平及组成进行了研究。发现慢性骨髓增殖性疾病中GAG水平升高。在大多数急性白血病病例中，该参数远低于正常水平。对GAG谱的评估确定了细胞GAG水平变化、增殖细胞类型与白血病转化之间的关系。确定了髓系和淋巴细胞中GAG谱的特点。结果表明，对白血病患者白细胞中GAG的研究可能有助于原始细胞的鉴定及白血病类型的鉴别诊断。
