犬类衰老项目：伴侣动物中的转化老年科学
The dog aging project: translational geroscience in companion animals.
作者信息
Kaeberlein Matt, Creevy Kate E, Promislow Daniel E L
机构信息
Department of Pathology, University of Washington, Seattle, WA, USA.
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
出版信息
Mamm Genome. 2016 Aug;27(7-8):279-88. doi: 10.1007/s00335-016-9638-7. Epub 2016 May 3.
Studies of the basic biology of aging have identified several genetic and pharmacological interventions that appear to modulate the rate of aging in laboratory model organisms, but a barrier to further progress has been the challenge of moving beyond these laboratory discoveries to impact health and quality of life for people. The domestic dog, Canis familiaris, offers a unique opportunity for surmounting this barrier in the near future. In particular, companion dogs share our environment and play an important role in improving the quality of life for millions of people. Here, we present a rationale for increasing the role of companion dogs as an animal model for both basic and clinical geroscience and describe complementary approaches and ongoing projects aimed at achieving this goal.
衰老基础生物学的研究已经确定了几种基因和药物干预措施，这些措施似乎可以调节实验室模式生物的衰老速度，但进一步取得进展的一个障碍是，如何从这些实验室发现迈向改善人类健康和生活质量。家犬（Canis familiaris）为在不久的将来克服这一障碍提供了独特的机会。特别是，宠物犬与我们共享环境，在改善数百万人的生活质量方面发挥着重要作用。在此，我们提出一个理由，即增加宠物犬作为基础和临床老年科学动物模型的作用，并描述旨在实现这一目标的补充方法和正在进行的项目。
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