阿卡波糖：对降低餐后高血糖及改善心血管结局安全有效。
Acarbose: safe and effective for lowering postprandial hyperglycaemia and improving cardiovascular outcomes.
作者信息
DiNicolantonio James J, Bhutani Jaikrit, O'Keefe James H
机构信息
Saint Luke's Mid America Heart Institute , Kansas City, Missouri , USA.
Pt BD Sharma PGIMS, Rohtak , Haryana , India.
出版信息
Open Heart. 2015 Oct 19;2(1):e000327. doi: 10.1136/openhrt-2015-000327. eCollection 2015.
Abstract
α-Glucosidase inhibitors (AGIs) are a class of oral glucose-lowering drugs used exclusively for treatment or prevention of type 2 diabetes mellitus. AGIs act by altering the intestinal absorption of carbohydrates through inhibition of their conversion into simple sugars (monosaccharides) and thus decrease the bioavailability of carbohydrates in the body, significantly lowering blood glucose levels. The three AGIs used in clinical practice are acarbose, voglibose and miglitol. This review will focus on the cardiovascular properties of acarbose. The current available data suggest that AGIs (particularly acarbose) may be safe and effective for the treatment of prediabetes and diabetes.
摘要
α-葡萄糖苷酶抑制剂（AGIs）是一类专门用于治疗或预防2型糖尿病的口服降糖药物。AGIs通过抑制碳水化合物转化为单糖来改变肠道对碳水化合物的吸收，从而降低碳水化合物在体内的生物利用度，显著降低血糖水平。临床实践中使用的三种AGIs是阿卡波糖、伏格列波糖和米格列醇。本综述将聚焦于阿卡波糖的心血管特性。目前可得的数据表明，AGIs（尤其是阿卡波糖）可能对治疗糖尿病前期和糖尿病安全有效。
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