3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study.

PURPOSE

To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T.

MATERIALS AND METHODS

A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis.

RESULTS

Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m , end systolic volume index (ESVI) = 22 ± 7 ml/m , stroke volume index (SVI) = 49 ± 8 ml/m , and LV mass index (LVMI) = 55 ± 12 g/m . The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m , ESVI 21v25 ml/m , SVI 46v52 ml/m , LVMI 49v64 g/m , all P < 0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m , females: -3.1 ± 0.8 ml/m ; ESVI males: -1.3 ± 0.7 ml/m , females: -1.7 ± 0.5 ml/m ; SVI males: -1.7 ± 0.9 ml/m , females: -1.4 ± 0.6 ml/m ; LVMI males: -1.6 ± 1.1 g/m , females: -0.2 ± 0.6 g/m ) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age.

CONCLUSION

LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners. J. Magn. Reson. Imaging 2016;44:1186-1196.