Boissoneault Jeff, Vatthauer Karlyn, O'Shea Andrew, Craggs Jason G, Robinson Michael, Staud Roland, Berry Richard B, Perlstein William, Waxenberg Lori, McCrae Christina S
a Pain Research and Intervention Center of Excellence , University of Florida , Gainesville , Florida.
b Department of Clinical and Health Psychology , University of Florida , Gainesville , Florida.
Behav Sleep Med. 2017 Nov-Dec;15(6):438-450. doi: 10.1080/15402002.2016.1150279. Epub 2016 May 4.
Fibromyalgia and chronic insomnia are frequently comorbid conditions with heightened sensitivity to painful stimuli, potentially subserved by the hippocampus. Recent evidence suggests moderate alcohol consumption is associated with reduced fibromyalgia symptom severity. We examined the relationship among alcohol use, hippocampal morphology, fibromyalgia, and insomnia symptom severity in 41 fibromyalgia patients (19 with insomnia). A 14-day diary of sleep, pain, and alcohol consumption was followed by structural MRI. Analyses indicated greater bilateral hippocampal volume, lower clinical pain intensity, and better sleep quality in moderate drinkers versus abstainers. Underlying mechanisms may include gamma-amino butyric acid (GABA) receptor agonism, n-methyl d-aspartate (NMDA) receptor antagonism, and psychosocial factors. Further study of the relationship between alcohol use and fibromyalgia and insomnia symptom severity is warranted.
纤维肌痛和慢性失眠常合并出现，对疼痛刺激的敏感性增强，这可能由海马体介导。最近的证据表明，适度饮酒与纤维肌痛症状严重程度降低有关。我们研究了41名纤维肌痛患者（19名伴有失眠）的饮酒情况、海马体形态、纤维肌痛和失眠症状严重程度之间的关系。在进行14天的睡眠、疼痛和饮酒情况记录后，进行了结构磁共振成像（MRI）检查。分析表明，与戒酒者相比，适度饮酒者双侧海马体体积更大、临床疼痛强度更低且睡眠质量更好。潜在机制可能包括γ-氨基丁酸（GABA）受体激动、N-甲基-D-天冬氨酸（NMDA）受体拮抗以及社会心理因素。有必要进一步研究饮酒与纤维肌痛和失眠症状严重程度之间的关系。
