Jansen Matthijs F, Hollander Maurits R, van Royen Niels, Horrevoets Anton J, Lutgens Esther
Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands.
Department of Medical Biochemistry, Academic Medical Centre, Meibergdreef 15, 1105AZ, Amsterdam, The Netherlands.
Basic Res Cardiol. 2016 Jul;111(4):38. doi: 10.1007/s00395-016-0554-5. Epub 2016 May 4.
Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is the leading cause of mortality in the western world, with developing countries showing a similar trend. With the increased understanding of the role of the immune system and inflammation in coronary artery disease, it was shown that macrophages play a major role in this disease. Costimulatory molecules are important regulators of inflammation, and especially, the CD40L-CD40 axis is of importance in the pathogenesis of cardiovascular disease. Although it was shown that CD40 can mediate macrophage function, its exact role in macrophage biology has not gained much attention in cardiovascular disease. Therefore, the goal of this review is to give an overview on the role of macrophage-specific CD40 in cardiovascular disease, with a focus on coronary artery disease. We will discuss the function of CD40 on the macrophage and its (proposed) role in the reduction of atherosclerosis, the reduction of neointima formation, and the stimulation of arteriogenesis.
冠状动脉疾病（CAD），也称为缺血性心脏病（IHD），是西方世界的主要死因，发展中国家也呈现出类似趋势。随着对免疫系统和炎症在冠状动脉疾病中作用的认识不断加深，研究表明巨噬细胞在这种疾病中起主要作用。共刺激分子是炎症的重要调节因子，特别是CD40L-CD40轴在心血管疾病的发病机制中具有重要意义。尽管已表明CD40可介导巨噬细胞功能，但其在巨噬细胞生物学中的确切作用在心血管疾病中并未受到太多关注。因此，本综述的目的是概述巨噬细胞特异性CD40在心血管疾病中的作用，重点是冠状动脉疾病。我们将讨论CD40在巨噬细胞上的功能及其在减少动脉粥样硬化、减少新生内膜形成和刺激动脉生成方面（可能）发挥的作用。
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