Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, 125315 Moscow, Russia.
Petrovsky National Research Centre of Surgery, 119991 Moscow, Russia.
Cells. 2023 Feb 5;12(4):522. doi: 10.3390/cells12040522.
A wide variety of cell populations, including both immune and endothelial cells, participate in the pathogenesis of atherosclerosis. Among these groups, macrophages deserve special attention because different populations of them can have completely different effects on atherogenesis and inflammation in atherosclerosis. In the current review, the significance of different phenotypes of macrophages in the progression or regression of atherosclerosis will be considered, including their ability to become the foam cells and the consequences of this event, as well as their ability to create a pro-inflammatory or anti-inflammatory medium at the site of atherosclerotic lesions as a result of cytokine production. In addition, several therapeutic strategies directed to the modulation of macrophage activity, which can serve as useful ideas for future drug developments, will be considered.
多种细胞群体，包括免疫细胞和内皮细胞，参与动脉粥样硬化的发病机制。在这些群体中，巨噬细胞值得特别关注，因为它们的不同群体对动脉粥样硬化的发生和炎症有完全不同的影响。在本综述中，将考虑不同表型的巨噬细胞在动脉粥样硬化进展或消退中的意义，包括它们成为泡沫细胞的能力及其后果，以及它们由于细胞因子产生而在动脉粥样硬化病变部位产生促炎或抗炎介质的能力。此外，还将考虑几种针对巨噬细胞活性调节的治疗策略，这些策略可为未来的药物开发提供有用的思路。
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