Otto Diels Institute of Organic Chemistry, Christiana Albertina University of Kiel, Otto-Hahn-Platz 3/4, D-24118 Kiel, Germany.
Chem Soc Rev. 2016 Jun 7;45(11):3275-302. doi: 10.1039/c6cs00165c. Epub 2016 May 5.
The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates. We are discussing primary, secondary and tertiary structural aspects including approaches to organize multivalency.
细胞表面碳水化合物以及可溶性糖缀合物与其受体蛋白的相互作用控制着细胞生物学的基本过程。糖识别的基础和调节的超分子原理之一是多价性。因此，已经合成了许多多价糖缀合物来研究糖生物学中起作用的多价效应。这篇综述的重点是较小的多价结构，如糖簇，强调以碳水化合物为中心和杂多价糖缀合物。我们正在讨论包括组织多价性的方法在内的一级、二级和三级结构方面。
