Dasinger John Henry, Intapad Suttira, Backstrom Miles A, Carter Anthony J, Alexander Barbara T
Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi.
Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi
Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F312-9. doi: 10.1152/ajprenal.00123.2016. Epub 2016 May 4.
Placental insufficiency programs an increase in blood pressure associated with a twofold increase in serum testosterone in male growth-restricted offspring at 4 mo of age. Population studies indicate that the inverse relationship between birth weight and blood pressure is amplified with age. Thus, we tested the hypothesis that intrauterine growth restriction programs an age-related increase in blood pressure in male offspring. Growth-restricted offspring retained a significantly higher blood pressure at 12 but not at 18 mo of age compared with age-matched controls. Blood pressure was significantly increased in control offspring at 18 mo of age relative to control counterparts at 12 mo; however, blood pressure was not increased in growth-restricted at 18 mo relative to growth-restricted counterparts at 12 mo. Serum testosterone levels were not elevated in growth-restricted offspring relative to control at 12 mo of age. Thus, male growth-restricted offspring no longer exhibited a positive association between blood pressure and testosterone at 12 mo of age. Unlike hypertension in male growth-restricted offspring at 4 mo of age, inhibition of the renin-angiotensin system with enalapril (250 mg/l for 2 wk) did not abolish the difference in blood pressure in growth-restricted offspring relative to control counterparts at 12 mo of age. Therefore, these data suggest that intrauterine growth restriction programs an accelerated age-related increase in blood pressure in growth-restricted offspring. Furthermore, this study suggests that the etiology of increased blood pressure in male growth-restricted offspring at 12 mo of age differs from that at 4 mo of age.
胎盘功能不全致使雄性生长受限后代在4月龄时血压升高，同时血清睾酮水平增加两倍。人群研究表明，出生体重与血压之间的反比关系会随着年龄增长而增强。因此，我们检验了这样一个假设：子宫内生长受限会导致雄性后代血压随年龄增长而升高。与年龄匹配的对照组相比，生长受限后代在12月龄时血压仍显著较高，但在18月龄时并非如此。与12月龄时的对照相比，对照组后代在18月龄时血压显著升高；然而，与12月龄时的生长受限后代相比，18月龄时生长受限后代的血压并未升高。与12月龄时的对照组相比，生长受限后代的血清睾酮水平并未升高。因此，雄性生长受限后代在12月龄时不再表现出血压与睾酮之间的正相关关系。与4月龄时雄性生长受限后代的高血压不同，用依那普利（250 mg/l，持续2周）抑制肾素-血管紧张素系统并不能消除12月龄时生长受限后代与对照后代之间的血压差异。因此，这些数据表明，子宫内生长受限会导致生长受限后代血压随年龄增长而加速升高。此外，这项研究表明，12月龄时雄性生长受限后代血压升高的病因与4月龄时不同。
