Crabtree Judy S, Singleton Ciera S, Miele Lucio
Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA; Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Department of Genetics, Louisiana State University Health Sciences Center , New Orleans, LA , USA.
Front Oncol. 2016 Apr 14;6:94. doi: 10.3389/fonc.2016.00094. eCollection 2016.
Carcinoids and neuroendocrine tumors (NETs) are a heterogeneous group of tumors that arise from the neuroendocrine cells of the GI tract, endocrine pancreas, and the respiratory system. NETs remain significantly understudied with respect to molecular mechanisms of pathogenesis, particularly the role of cell fate signaling systems such as Notch. The abundance of literature on the Notch pathway is a testament to its complexity in different cellular environments. Notch receptors can function as oncogenes in some contexts and tumor suppressors in others. The genetic heterogeneity of NETs suggests that to fully understand the roles and the potential therapeutic implications of Notch signaling in NETs, a comprehensive analysis of Notch expression patterns and potential roles across all NET subtypes is required.
类癌和神经内分泌肿瘤（NETs）是一组异质性肿瘤，起源于胃肠道、内分泌胰腺和呼吸系统的神经内分泌细胞。就发病机制的分子机制而言，NETs仍未得到充分研究，尤其是细胞命运信号系统（如Notch）的作用。关于Notch通路的大量文献证明了其在不同细胞环境中的复杂性。Notch受体在某些情况下可作为癌基因发挥作用，而在其他情况下则可作为肿瘤抑制因子。NETs的基因异质性表明，要全面了解Notch信号在NETs中的作用及其潜在的治疗意义，需要对所有NET亚型的Notch表达模式和潜在作用进行综合分析。
